Faculty Research and Program Support

Faculty research picture The CCAH provides grant funding on a competitive basis to faculty for studies dedicated to advancing the health of dogs, cats and exotic pets. For over 30 years the CCAH has been supporting these efforts, and has awarded more than $26 million. In 2025-2026, the CCAH provided $2,317,447 in faculty research support.

FACULTY GRANTS FUNDED

CCAH awarded faculty grants for 2025-2026 include:

Dog Research Studies

Identification of germline L1 transposable elements that mobilize in canine osteosarcoma (Bannasch)

Infectious contributors to canine hemangiosarcoma: A multi-Omics pilot study (Brady)

Validation of an ELISA to measure thrombospondin-1 in dogs with immune-mediated hemolytic anemia (Viall)

Clinical evaluation of a theragnostic (diagnostic and therapeutic) anti- PDL-1 fluorescence imaging (Goldschmidt)

Epidemiology of canine uropathogenic Escherichia coli infections through pangenome sequence analysis (Sykes)

Identifying mobile Line-1 elements in Golden Retriever tumors through long-read sequencing (Bannasch)

Canine brain organoid model of Lafora disease for NHLRC1 gene therapy development (Kol)

Ezrin-dependent mechanosensing as a regulator of bone remodeling; a pilot study (Yellowley)

IL-15 and anti-PD-L1 antagonism in canine cancer: platform optimization and mechanistic dissection (Brady)

Immunology of invasive mold infections in dogs (Vapniarsky Arzi)

Chromogranin A in healthy dogs and dogs with neuroendocrine neoplasia (Kent)

Colon-microbiota signaling changes during episodes of chemotherapy-associated vomiting and diarrhea (Savage)

Comprehensive variant calling for metaphyseal osteopathy (Bannasch)

Does thrombospondin-1 cause thrombosis and hemolysis in canine immune-mediated hemolytic anemia?(Viall)

Effects of disulfiram in dogs with sudden acquired retinal degeneration syndrome (Thomasy)

Effects of implant orientation and anconeal ostectomy on impingement in canine elbow replacement (Lu)

Evaluation of amino acid adequacy of commercial plant-based diets for dogs (Larsen)

Fluorescence-guided surgery using 5-aminolevulinic acid for canine brain tumors (Dupanloup)

Immune profiling of toceranib therapy in dogs: Linking STAT3 inhibition to myeloid and lymphoid responses (Kent)

Mitochondrial transfer and subsequent metabolic adaptations in glioma stem-like cells (Toedebusch)

Oliguria in critically ill dogs: associations with clinical management and outcomes (Philip)

Radiation dose-response and immune priming in canine tumor-draining lymph nodes (Lawrence)

Targeting ferroptosis for the treatment of canine melanoma (Chen)

Therapeutic potential of cuproptosis in canine osteosarcoma (Zhang)

Validation of novel 3D printed canine vertebrae for surgical training (Dilip-Murthy)

Nutritional analysis of selected commercial canine low-fat diets (Stockman)

Peripheral immune signatures as prognostic markers in canine lung cancer (Brady)

Utility of thoracic CT in assessment of dogs with osteosarcoma treated with palliative amputation (Latifi)

Cat Research Studies

Bartonella infection and clinical outcomes in immunosuppressed cats: A prospective cohort study (Lashnits)

Profiling the immune–endocrine interface in feline hypersomatotropism through hypophysectomy (Dupanloup)

Whole blood transcriptomic profiling of pruritus in feline atopic skin syndrome (Jordan)

Biomarker discovery from integrated blood multi-omics analysis in feline chronic kidney disease (Giulivi)

Pilot pharmacokinetic study of palbociclib in cats with oral squamous cell carcinoma (Brady)

Comparison of two viscoelastic assessments in cats with and without hypertrophic cardiomyopathy (Jandrey)

Determining phosphorus content in cat treats and supplements (Stockman)

Development of a 3-D feline blood brain barrier on a chip to enable FIP antiviral delivery testing (Brostoff)

Longitudinal MRI evaluation following endoscopic surgical treatment of hydrocephalus in kittens (Lim)

Endoscopic third ventriculostomy in kittens with congenital obstructive hydrocephalus (Lim)

Companion Animal Research Studies

Age-related pharmacokinetics of meloxicam in adult and geriatric axolotls (Ambystoma mexicanum) (Rogers)

Are plasma terbinafine concentrations dependent upon sex in Pogona vitticeps? (Keller)

Exploring potential nutritional gaps in commercial diets for omnivorous geckos under human care (Stockman)

Identification and characterization of Tenacibaculum spp. in fish (Soto-Martinez)

Validation of low-volume blood typing techniques in dogs and cats (Epstein)

Development and testing of a cancer registry for dogs and cats using the data from the UC Davis-VMTH (Martinez-Lopez)

Comparative spatio-temporal analysis of cancer incidence in companion animals and humans (Martinez-Lopez)

Perioperative assessment of electroencephalography in dogs with congenital portosystemic shunts
Dupanloup AM, Dickinson PJ, Toedebusch CM, Unkel CM, Culp WTN, Knipe MF

This study evaluated whether EEG testing could identify dogs at risk for neurological complications following surgery for congenital portosystemic shunts. Dogs with normal preoperative EEGs had favorable outcomes during hospitalization, suggesting EEG may help identify dogs at higher risk for postoperative seizures and other complications.
Safety and efficacy of a STAT3-targeted cyclic oligonucleotide: From murine models to a phase 1 clinical trial in pet cats with oral cancer
Grandis JR, Skorupski KA, Cheng N, Cui Z, Li H, Woerner LC, Gencel-Augusto J, Zeng Y, Shiah JV, Bhola NE, Sen M, Blum K, Kim MO, York D, Rebhun RB, Chang H, Murad NF, Olshen AB, Sparger EE, Johnson DE

This study evaluated a new therapy targeting STAT3, a protein that promotes cancer growth and suppresses the immune response, in cats with head and neck cancer. The treatment helped control disease in 35% of cats and identified immune differences associated with response, supporting further evaluation of this approach in both veterinary and human cancer patients.
Biomechanical evaluation of two plating systems for fixation of mandibular condylar process fractures in dogs demonstrates sustainability under bite forces
Evenhuis JV, Desvages A, Nguyen MA, Garcia TC, Goldschmidt SL, Arzi B

This study evaluated two titanium plating systems as a potential surgical treatment for challenging jaw fractures involving the temporomandibular joint in dogs. Both plate designs could be successfully placed and withstood forces greater than normal biting forces, supporting their potential use to restore jaw stability and function in medium- to large-breed dogs.

2025-2026 CCAH published donor funded studies:

Artificial Intelligence

Anna: an open-source platform for real-time integration of machine learning classifiers with veterinary electronic health records
BMC Veterinary Research
(October 2025)
Kong CY, Vasquez P, Farhoodimoghadam M, Brandt C, Brown TC, Reagan KL, Zwingenberger A, Keller SM

Cancer

Comparison of interpatient and intrapatient variability in doxorubicin exposure using a validated limited sampling model in dogs with cancer
Veterinary Oncology
(October 2025)
Veluvolu SM, Rebhun RB, Kim J, Wittenburg LA

Defining variations in the size of normal pituitary glands and pituitary macrotumors based on canine skull morphology
Veterinary Radiology and Ultrasound
(January 2026)
Pham HV, Brust KD, Lawrence JA, Rosseel M, Kent MS

Heterogeneous DNA methylation and gene expression patterns underly metabolic plasticity in canine astrocytoma-derived stem-like cells
Frontiers in Oncology
(January 2026)
Toedebusch RG, Hwang C, Syed-Quadri S, Aboud O, Woolard KD, York D, Parys M, Dickinson PJ, Meyers FJ, McPherson JD, Toedebusch CM

Descriptive epidemiology of canine and feline cancer in California, United States from 2000 to 2019
The Veterinary Journal
(June 2026)
Rupasinghe R, Díaz Cao JM, Kent M, Lejeune AT, Rebhun RB, Martínez-López B

Cardiology

Oral pravastatin administered in food but not drinking water reaches target plasma concentrations in cockatiels (Nymphicus hollandicus)
American Journal of Veterinary Research
(June 2026)
Liles M, Knych H, Guzman DSM, Beaufrère H

Dentistry

Biomechanical evaluation of two plating systems for fixation of mandibular condylar process fractures in dogs demonstrates sustainability under bite forces
American Journal of Veterinary Research
(December 2025)
Evenhuis JV, Desvages A, Nguyen MA, Garcia TC, Goldschmidt SL, Arzi B

Evaluating cone-beam computed tomography versus intraoral radiography for the detection of endodontal disease in dogs: diagnostic performance and inter-rater agreement
Frontiers in Veterinary Science
(August 2026)
Bonacini S, Goldschmidt S, Arzi B, Vapniarsky N, Lommer M, Blandino A, Hatcher D, Soltero-Rivera M

Cytokine priming shifts mitochondrial architecture and extracellular vesicle cargo of feline placental mesenchymal stromal cells toward an immunosuppressive phenotype
American Journal of Veterinary Research
(October 2026)
Soltero-Rivera M, Arzi B, Marycz K

Dermatology

In vitro efficacy of disinfectants against Nannizziopsis arthrosporioides
Journal of Zoo and Wildlife Medicine
(June 2026)
Liles MR, Keller KA

Genetics

A variant in RESF1 is associated with Addison’s disease and multiple autoimmune syndrome in young Nova Scotia Duck Tolling Retrievers
Scientific Reports
(March 2026)
Brown E, Varney S, Young A, Wolf Z, Foreman O, Wade CM, Hughes A, Oberbauer A, Safra N, Lindblad-Toh K, Burton S, Bannasch D

A splice acceptor variant in DLL3 is associated with spondylocostal dysostosis in a litter of mixed-breed dogs
Genes
(January 2026)
Varney S, Vernau K, Brown C, Toedebusch C, Vo J, Bannasch D

Infectious Disease

Clinical and clinicopathologic features of an undifferentiated resolving uveitis in kittens similar to that seen with feline infectious peritonitis
Journal of the American Veterinary Medical Association
(May 2026)
Shiraishi H, Vernau KM, Choi E, Dubelko AR, Purpura J, Dear JD, Hollingsworth SR, Thomasy SM, Good KL, Wiggans KT, Murphy BG, Kass PH, Maggs DJ

Beyond macrophages: FIPV tropism includes T and B lymphocytes
Veterinary Microbiology
(February 2026)
Balakumar A, Wanakumjorn P, Kimura K, McLarty E, Farrell K, Brostoff T, Pires J, Cohen-Davidyan T, Cassano JM, Murphy B, Reagan K, Kol A

Treatment of non-effusive feline infectious peritonitis using oral remdesivir or GS-441524: a randomized, double-blind, non-inferiority trial
Journal of Feline Medicine and Surgery
(March 2026)
Brostoff T, Pires J, Rose A, Cohen-Davidyan T, Castillo D, Murphy BG, Reagan KL

Internal Medicine

Urinary cystine/creatinine concentrations before and after castration in dogs with suspected androgen-dependent cystine urolithiasis
Journal of Veterinary Internal Medicine
(November 2025)
Larsen JA, Hulsebosch SE, Fine J, Johnson EG, Pires J, Henthorn PS, Westropp JL

Nutrition

Analysis of essential minerals and heavy metals in canine and feline dietary supplements marketed in the United States
Journal of Animal Physiology and Animal Nutrition
(March 2026)
Pestalozzi TK, Fascetti AJ, Larsen JA

Neurology

Perioperative assessment of electroencephalography in dogs with congenital portosystemic shunts
Journal of Veterinary Internal Medicine
(January 2026)
Dupanloup AM, Dickinson PJ, Toedebusch CM, Unkel CM, Culp WTN, Knipe MF

Regenerative Medicine

Delayed isolation and cryopreservation have significant effects on the yield and proliferation of feline peripheral blood mononuclear cells
American Journal of Veterinary Research
(July 2025)
Rivas I, Li Z, Irvin J, Huda N, Arzi B, Vapniarsky N

Surgery / Orthopedics

Comparison between a laparoscopic articulating needle driver with standard laparoscopic instrumentation for total laparoscopic gastropexy in dogs
Veterinary Surgery
(February 2026)
Gibson EA, Culp WTN, Balsa IM, Steffey M, Mayhew P

Folded-flap palatoplasty and traditional staphylectomy yield similar postoperative soft palate geometry in French Bulldogs undergoing airway surgery
Journal of the American Veterinary Medical Association
(April 2026)
Farrell M, Singh A, Mayhew PD, Hawker W, Collier A, Appleby R, Sanchez A, Bersenas A, Ullal T, Marks SL, Chohan A, Brinkley ASL

Prior Publications

2024-2025 CCAH published donor funded studies:
Aging
A non-randomized pilot study to test the feasibility of developing a frailty scale for pet cats
Frontiers in Veterinary Science
(February 2025)
Colleran EJ, Delgado MM, Ren Y, German AJ, Gruen ME, Gunn-Moore DA, Romanowski K, Simpson W, Kirnos C, Ternes KK, Karnia J, Temples M, Taylor SL, Bain M, Buffington CAT
Anesthesia
Increasing plasma ketamine concentrations decrease the minimum alveolar concentration of isoflurane in rabbits
Frontiers in Veterinary Science
(June 2025)
Pypendop BH, Cenani A, Machado ML, Barter LS
Target-controlled infusions of butorphanol worsen hemodynamics in isoflurane-anesthetized cats
Frontiers in Veterinary Science
(February 2025)
Colleran EJ, Delgado MM, Ren Y, German AJ, Gruen ME, Gunn-Moore DA, Romanowski K, Simpson W, Kirnos C, Ternes KK, Karnia J, Temples M, Taylor SL, Bain M, Buffington CAT
Ultrasound-guided trigeminal nerve approach at the level of the terygopalatine fossa in cat cadavers
Veterinary Anaesthesia and Analgesia
(November-December 2024)
Fernandez Barrientos MA, Cenani A, Brown CS, Arzi B, Wolfs E, Pypendop BH
Cancer
Artificial intelligence-based quantification of lymphocytes in feline small intestinal biopsies
Veterinary Pathology
(March 2025)
Wulcan JM, Giaretta PR, Fingerhood S, de Brot S, Crouch EEV, Wolf T, Casanova MI, Ruivo PR, Bolfa P, Streitenberger N, Bertram CA, Donovan TA, Keel MK, Moore PF, Keller SM
Safety and efficacy of a STAT3-targeted cyclic oligonucleotide: From murine models to a phase 1 clinical trial in pet cats with oral cancer
Cancer Cell
(August 2025)
Grandis JR, Skorupski KA, Cheng N, Cui Z, Li H, Woerner LC, Gencel-Augusto J, Zeng Y, Shiah JV, Bhola NE, Sen M, Blum K, Kim MO, York D, Rebhun RB, Chang H, Murad NF, Olshen AB, Sparger EE, Johnson DE
Do pre-treatment biopsy characteristics predict early tumour progression in feline diffuse large B cell nasal lymphoma treated with radiotherapy?
Veterinary and Comparative Oncology
(March 2025)
Poirier VJ, Meier V, Turek M, Christensen N, Bowal J, Ponzini MD, Keller SM
Effect of glyceryl trinitrate and clevidipine administration on CT angiogram findings in dogs undergoing prostatic artery embolization for prostatic carcinoma
PLOS ONE
(December 2024)
Veluvolu S, Willcox JL, Skorupski KA, Al-Nadaf S, Rebhun R, Wittenburg L
Dentistry
Preliminary characterisation of immune cell populations in the oral mucosa of a small cohort of healthy dogs (Canis lupus familiaris)
Anatomia, Histologia, Embryologia
(November 2024)
Soltero-Rivera M, Bailey M, Blandino A, Arzi B, Vapniarsky N
Impact of pro-inflammatory cytokine preconditioning on metabolism and extracellular vesicles in feline mesenchymal stromal cells: a preliminary study
Stem Cells
(June 2025)
Soltero-Rivera M, Arzi B, Bourebaba L, Marycz K
Infectious Disease
Mesenchymal stem/stromal cell therapy improves immune recovery in a feline model of severe coronavirus infection
Stem Cells Translational Medicine
(June 2025)
Wanakumjorn P, Kimura K, Castillo D, McLarty E, Formaker R, Qiao R, Farrell K, Brostoff T, Ramarapu R, Pires J, Cohen-Davidyan T, Cassano J, Murphy B, Reagan K, Kol A
The nucleoside analog GS-441524 effectively attenuates the In vitro replication of multiple lineages of circulating canine distemper viruses isolated from wild North American carnivores
Viruses
(January 2025)
Oliver-Guimera A, Murphy BG, Keel MK
Doxycycline with or without famciclovir for infectious ophthalmic and respiratory disease: a prospective, randomized, masked, placebo-controlled trial in 373 kittens
Journal of Feline Medicine and Surgery
(November 2024)
Vernau KM, Kim S, Thomasy SM, Lucyshyn DR, Purpura J, Montgomery E, Surmick JD, Dubelko AR, Moussavi A, Kass PH, Maggs DJ
Open label clinical trial of orally administered molnupiravir as a first-line treatment for naturally occurring effusive feline infectious peritonitis
Journal of Veterinary Internal Medicine
(November-December 2024)
Reagan KL, Brostoff T, Pires J, Rose A, Castillo D, Murphy BG
Immunology
Single cell RNA-sequencing of feline peripheral immune cells with V(D)J repertoire and cross species analysis of T lymphocytes
Frontiers in Immunology
(November 2024)
Ramarapu R, Wulcan JM, Chang H, Moore PF, Vernau W, Keller SM
Internal Medicine
Trace element content is associated with urolith type in goats and pigs diagnosed with urolithiasis
American Journal of Veterinary Research
(April 2025)
Chigerwe M, Killilea DW, Hardgrove CN, Mann U, Stoller ML, Westropp JL
Effects of plasma and hetastarch administration on colloid oncotic pressure and coagulation parameters in dairy calves and goats
Journal of Veterinary Internal Medicine
(May-June 2025)
Cuneo SW, Abi-Nader BA, Blasczynski SJ, Chigerwe M
Nutrition
Fatty acid analysis and stability of selected edible oils used in homemade pet diets
Journal of Veterinary Internal Medicine
(May 2025)
Larsen JA, Stockman J, Li X, Wang SC
Diurnal variation of serum phosphorus concentrations in intact male adult domestic cats
Journal of Veterinary Internal Medicine
(November-December 2024)
Chiang CF, Vanderstichel R, Stockman J, Larsen JA, Fascetti AJ
Ophthalmology
Ocular tolerance and tear film pharmacokinetics of 1 % penciclovir cream in cats
Research in Veterinary Science
(September 2025)
Pe'er O, Thomasy SM, Feuer E, Knych HK, Ofri R, Sebbag L
Pain
Pharmacokinetics of single-dose oral acetaminophen with and without concurrent administration of silymarin or N-acetylcysteine in orange-winged Amazon parrots (Amazona amazonica)
American Journal of Veterinary Research
(March 2025)
Megan L, Sanchez-Migallon Guzman D, Knych H, Beaufrère HH
Surgery / Orthopedics
Subclinical gastrointestinal mucosal lesions occur in dogs with intrahepatic portosystemic shunts independent of percutaneous transvenous coil embolization
Journal of the American Veterinary Medical Association
(February 2025)
Gibson EA, Culp WTN, Hardy BT, Giuffrida MA, Balsa IM, Mayhew P, Marks SL
Radiographs acquired before total hip replacement in dogs underestimate femoral canal flare and misjudge trochanteric overhang
American Journal of Veterinary Research
(April 2025)
Bae S, Marcellin-Little DJ, Pritikin R, Garcia TC
Patient-specific 3D-printed nasopharyngeal stents in dogs: a cadaveric pilot study
Frontiers in Veterinary Science
(November 2024)
Sutter C, Hardy B, Lucero S, Johnson L, Culp W
2023-2024 CCAH published donor funded studies:
Anesthesia
Correlation, agreement and concordance of cardiac output estimated by transthoracic ultrasound and transesophageal Doppler with pulmonary artery thermodilution in anesthetized cats
Veterinary Anaesthesia and Analgesia
(November 2024)
Pypendop BH, Rivas VN, Bueno MC, Chohan AS, Barter LS, Stern JA

Effects of trazodone and dexmedetomidine on fentanyl-mediated reduction of isoflurane minimum alveolar concentration in cats
Veterinary Anaesthesia and Analgesia
(January 2024)
Brosnan RJ, Pypendop BH, Cenani A

Cancer
Development of a flow cytometric panel to assess prognostic biomarkers in fine needle aspirates of canine cutaneous or subcutaneous mast cell tumors
Frontiers in Veterinary Science
(November 2023)
Wu BX, Lejeune A, Affolter VK, Iamone G, Riondato F, Kol A

Isoform-specific disruption of the TP73 gene reveals a critical role for TAp73γ in tumorigenesis via leptin
eLife
(August 2023)
Kong X, Yan W, Sun W, Zhang Y, Yang HJ, Chen M, Chen H, de Vere White RW, Zhang J, Chen X
TP73 Isoform-specific disruption reveals a critical role of TAp73beta in growth suppression and inflammatory response
CDDpress
(January 2023)
Zhang J, Sun W, Yan W, Kong X, Shen T, Laubach K, Chen M, Chen X
Cardiology
Evaluation of clopidogrel response in healthy cats using a novel viscoelastic test and thromboelastography
Frontiers in Veterinary Science
(June 2024)
Rosati T, Jandrey KE, Stern JA, Nguyen N, Li RHL
Platelet hyperresponsiveness and increased platelet-neutrophil aggregates in dogs with myxomatous mitral valve disease and pulmonary hypertension
Journal of Veterinary Internal Medicine
(May 2024)
Duler L, VisserL, Nguyen N, Johnson LR, Stern JA, Li RHL
Genetics
Naturally occurring canine laminopathy leading to a dilated and fibrosing cardiomyopathy in the Nova Scotia Duck Tolling Retriever
Scientific Reports
(November 2023)
Bannasch DL, Oertle DT, Vo J, Batcher KL, Stern JA, Kaplan JL, Li RHL, Madden IE, Christen M, Leeb T, Joshi N
Association of the FGF4L2 retrogene with fibrocartilaginous embolic myelopathy in dogs
Journal of Veterinary Internal Medicine
(November 2023)
Embersics C, Bannasch D, Batcher K, Boudreau EC, Church M, Miller A, Platt S, Koehler J, Olby N, Rossmeisl J, Rissi D, Grahn R, Donner J, Dickinson PJ
Infectious Disease
Feline Infectious Peritonitis mRNA vaccine elicits both humoral and cellular immune responses in mice
Vaccines
(June 2024)
Brostoff T, Savage HP, Jackson KA, Dutra JC, Fontaine JH, Hartigan-O’Connor DJ, Carney RP, Pesavento PA
Serologic, virologic and pathologic features of cats with naturally occurring Feline Infectious Peritonitis enrolled in antiviral clinical trials
Viruses
(March 2024)
Murphy BG, Castillo D, Neely NE, Kol A, Brostoff T, Grant CK, Reagan KL
Prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and feline enteric coronavirus (FECV) in shelter-housed cats in the Central Valley of California, USA
VetRecord
(September 2023)
Chen D, López-Pérez AM, VernauKM, MaggsDJ, KimS, FoleyJ
The late asymptomatic and terminal immunodeficiency phases in experimentally FIV-infected cats—A long-term study
Viruses
(August 2023)
Murphy BG, Castillo D, Cook S, Eckstrand C, Evans S, Sparger E, Grant CK
Nutrition
Exploring the impact of age, and body condition score on erythrocytic B1-Dependent transketolase activity in cats: A comprehensive analysis of thiamine status
Heliyon
(July 2024)
Fascetti AJ, Larsen JA, Min A, Nair M, Montano M, Giulivi C
Factors influencing vitamin B6 status in domestic cats: age, disease, and body condition score
Scientific Reports
(January 2024)
Chu V, Fascetti AJ, Larsen JA, Montano M, Giulivi C
Pharmacokinetics
Pharmacokinetics of single-dose oral atorvastatin and its metabolites support therapeutic use in orange-winged Amazon parrots (Amazona amazonica)
American Journal of Veterinary Research
(December 2023)
Mikoni N, Guzman DSM, Knych H, Beaufrère H
Renal
A lentivirus-vectored feline erythropoietin gene therapy strategy in tissue culture and rodent models for the potential treatment of chronic renal disease-associated anemia
American Journal of Veterinary Research
(April 2024)
Cook SE, Castillo D, Wolf T, Hillman C, Bauer K, Williams S, Murphy BG
Regenerative Medicine
Distinctive characteristics of extracellular vesicles from feline adipose and placenta stromal cells unveil potential for regenerative medicine in cats
Journal of the American Veterinary Medical Association
(March 2024)
Soltero-Rivera M, Arzi B, Bourebaba L, Marycz K
Spay / Neuter
Assisting decision-making on age of neutering for German Short/Wirehaired Pointer, Mastiff, Newfoundland, Rhodesian Ridgeback, Siberian Husky: associated joint disorders, cancers, and urinary incontinence
Frontiers in Veterinary Science
(April 2024)
Hart LA, Thigpen AP, Hart BL, Willits NH, Lee M, Babchuk MM, Lee J, Ho M, Clarkson ST, Chou JW

Surgery / Orthopedics
K-wire is more damaging than standard or acrylic drill bits when evaluating torsional properties of rabbit (Oryctolagus cuniculi) femurs
American Journal of Veterinary Research
(June 2024)
Massie AM, Kapatkin AS, Garcia TC, Marcellin-Little DJ, Guzman DSM, Chou PY, Stover SM
Evaluation of mediastinoscopy for cranial mediastinal and tracheobronchial lymphadenectomy in canine cadavers
Veterinary Surgery
(April 2024)
Gibson EA, Brust K, Steffey MA
Kinematic performance of a novel temporomandibular joint replacement prosthesis under bite-force conditions in dogs and cats
American Journal of Veterinary Research
(March 2024)
Weed M, Garcia TC, Goldschmidt SL, Marcellin-Little DJ
Computed tomographic lymphangiography following percutaneous intrahepatic injection of iopamidol in cats
American Journal of Veterinary Research
(January 2023)
Johnson EG, Mayhew PD, Runge JL
2022-2023 CCAH published donor funded studies:
Anesthesia
Pharmacokinetics of buprenorphine and its metabolite norbuprenorphine in neutered male cats anesthetized with isoflurane
Veterinary Anaesthesia and Analgesia
(July 2023)
Pypendop BH, Stoddard S, Barter LS

Effects of dopamine, norepinephrine or phenylephrine on the prevention of hypotension in isoflurane-anesthetized cats administered vatinoxan or vatinoxan and dexmedetomidine
Veterinary Anaesthesia and Analgesia
(January 2022)
Kobluk K, Pypendop BH

Cancer
A variant in the 5′UTR of ERBB4 is associated with lifespan in Golden Retrievers
Geroscience
(October 2023)
Rebhun RB, York D, De Graaf FMD, Yoon P, Batcher KL, Luker ME, Ryan S, Peyton J, Kent MS, Stern JA, Bannasch DL

Changes in diet and supplement use in dogs with cancer
Journal of Veterinary Internal Medicine
(August 2023)
Kramer ML, Larsen JA, Kent MS
Intra- and Intertumoral Microglia/Macrophage Infiltration and Their Associated Molecular Signature Is Highly Variable in Canine Oligodendroglioma: A Preliminary Evaluation
Veterinary Sciences
(June 2023)
Grigg EK, Liu S, Dempsey DG, Wong K, Bain M, Sollers JJ, Haddock R, Kogan LR, Barnhard JA, Tringali AA, Thigpen AP, Hart, LA
Fractionated oral dosing and its effect on cyclophosphamide pharmacokinetics in dogs with high-grade multicentric lymphoma
Veterinary and Comparative Oncology
(March 2023)
Veluvolu S, Willcox JL, Skorupski KA, Al-Nadaf S, Rebhun R, Wittenburg L
Longevity and mortality in cats: A single institution necropsy study of 3108 cases (1989-2019)
PLOS ONE
(December 2022)
Kent MS, Karchemskiy S, Culp WTN, Lejeune AT, Pesavento PA, Toedebusch C, Brady R, Rebhun R
Fluid Therapy
Continuous fluid infusion per rectum compared with intravenous fluid infusion in pigs
Journal of Veterinary Internal Medicine
(August 2023)
Chigerwe M, Blasczynski SJ, Abi-Nader BA, Condy PM, Kretsch CM, Depenbrock SM
Genetics
FGF4L2 retrogene copy number is associated with intervertebral disc calcification and vertebral geometry in Nova Scotia Duck Tolling Retrievers
American Journal of Veterinary Research
(January 2023)
Bianchi CA, Marcellin-Little DJ, Dickinson PJ, Garcia TC, Li CF, Batcher K, Bannasch DL
Infectious Disease
Clinical assessment of a point-of-care assay to determine protective vaccinal antibody titers to canine viral diseases
The Veterinary Journal
(September 2023)
Ad Y, Halperin IM, Olstad EC, Gershwin LJ, Sullivan L, Reagan KL
Efficacy of oral Remdesivir compared to GS-441524 for treatment of cats with naturally occurring effusive Feline Infectious Peritonitis: A blinded, non-inferiority study
Viruses
(August 2023)
Cosaro E, Pires J, Castillo D, Murphy BG, Reagan KL
Characteristics of extended-spectrum β-lactamase producing enterobacterales isolated from dogs and cats, 2011-2021
Veterinary Sciences
(February 2023)
Woerde DJ, Reagan KL, Byrne BA, Weimer BC, Epstein SE, Schlesener C, Huang BC, Sykes JE
Tyzzer disease in 19 preweaned orphaned kittens
Journal of Veterinary Diagnostic Investigation
(March 2023)
Fingerhood S, Mendonca FS, Uzal FA, Marks SL, Vernau KM, Navarro MA, Choi EA

An optimized bioassay for screening combined anticoronaviral compounds for efficacy against Feline Infectious Peritonitis virus with pharmacokinetic analyses of GS-441524, Remdesivir, and Molnupiravir in cats
Viruses
(May 2022)
Cook S, Wittenburg L, Yan VC, Theil JH, Castillo D, Reagan KL, Williams S, Pham CD, Li C, Muller FL, Murphy BG
Efficacy of a multidose acyclovir protocol against cyprinid herpesvirus 3 infection in koi (Cyprinus carpio)
American Journal of Veterinary Research
(November 2022)
Sosa-Higareda M, Yazdi Z, Littman EM, Quijano Carde EM, Yun S, Soto E
Neurology
Oral cytarabine ocfosfate pharmacokinetics and assessment of leukocyte biomarkers in normal dogs
Journal of Veterinary Internal Medicine
(September 2023)
Zwueste DM, Vernau KM, Vernau W, Pypendop BH, Knych HK, Rodrigues CA, Kol A, Questa M, Dickinson PJ
Tolerability and pharmacokinetics of intravenous allopregnanolone with and without midazolam pretreatment in two healthy dogs
Epilepsia Open
(January 2023)
Bruun DA, MA B, Chen YJ, Wu CY, Aleman M, Zolkowska D, Smiley-Jewell SM, Rogawski MA, Lein PJ
Ophthalmology
Symblepharon in kittens: a retrospective study of 40 kittens and 54 eyes (2002-2022)
Journal of Feline Medicine and Surgery
(February 2023)
Bruun DA, MA B, Chen YJ, Wu CY, Aleman M, Zolkowska D, Smiley-Jewell SM, Rogawski MA, Lein PJ
The TGM2 inhibitor cysteamine hydrochloride does not impact corneal epithelial and stromal wound healing in vitro and in vivo
Experimental Eye Research
(January 2023)
Minella AL, Casanova MI, Chokshi TJ, Kang J, Cosert K, Gragg MM, Bowman MA, Mccorkell ME, Daley NL, Leonard BC, Murphy CJ, Raghunathan VK, Thomasy SM
Ocular morphologic traits in the American Cocker Spaniel may confer primary angle closure glaucoma susceptibility
Scientific Reports
(November 2022)
Park S, Casanova MI, Bannasch DL, Daley NL, Kim S, Kuchtey J, Gomes FE, Leonard BC, Good KL, Da Costa Martins B, Murphy CJ, Thomasy SM
Topical Ripasudil for the treatment of primary corneal endothelial degeneration in dogs
Translational Vision Science and Technology
(September 2022)
Michalak SR, Kim S, Park S, Casanova MI, Bowman MAW, Ferneding M, Leonard BC, Good KL, Li JY, Thomasy SM

Pain Management
Twice-daily oral administration of a cannabidiol and cannabidiolic acid-rich hemp extract was well tolerated in orange-winged Amazon parrots (Amazona amazonica) and has a favorable pharmacokinetics profile
American Journal of Veterinary Research
(February 2023)
Sosa-Higareda M, Sanchez-Migallon Guzman D, Knych H, Lyubimov A, Zakharov A, Gomez B, Beaufrere H
Respiratory
Prospective evaluation of the efficacy of inhaled steroids administered via the AeroDawg spacing chamber in management of dogs with chronic cough
Journal of Veterinary Internal Medicine
(March 2023)
Chan JC, Johnson LR
Surgery/Orthopedics
Metal reactivity is present in dogs with tibial plateau leveling osteotomy and total hip replacement implants
American Journal of Veterinary Research
(January 2023)
Filliquist B, McKay R, Marcellin-Little DJ, Irvin JJ, Garcia TC, Vernau W, Chou PY, Kapatkin AS, Vapniarsky N
2021-2022 CCAH published donor funded studies:
Anesthesia
Cardiovascular and gas exchange effects of individualized positive end-expiratory pressures in cats anesthetized with isoflurane
Frontiers in Veterinary Science
(May 2022)
Machado ML, Soares JHN, Pypendop BH, Aguiar AJA, Braun C, Motta-Ribeiro GC, Jandre FC

Pharmacokinetics of butorphanol in male neutered cats anesthetized with isoflurane
Journal of Veterinary Pharmacology and Therapeutics
(September 2021)
Pypendop BH, Shilo-Benjamin Y

Pharmacokinetics of grapiprant administered to red-tailed hawks (Buteo jamaicensis) after food was withheld for 24 hours
American Journal of Veterinary Research
(November 2021)
Rodriguez P, Paul-Murphy JR, Knych HK, Drazenovich TL, Hawkins MG
Behavior
How does the social grouping of animals in nature protect against sickness? A perspective
Frontiers in Behavioral Neuroscience
(July 2021)
Hart LA, Hart BL

Stress-related behaviors in companion dogs exposed to common household noises, and owners' interpretations of their dogs' behavior
Frontiers in Behavioral Neuroscience
(November 2021)
Grigg EK, Chou J, Parker E, Gatesy-Davis A, Clarkson ST, Hart LA
Assessing the relationship between the emotional states of dogs and their human handlers, using simultaneous behavioral and cardiac measures
Frontiers in Veterinary Science
(July 2022)
Grigg EK, Liu S, Dempsey DG, Wong K, Bain M, Sollers JJ, Haddock R, Kogan LR, Barnhard JA, Tringali AA, Thigpen AP, Hart, LA
Companion animals’ roles for AIDS survivors, mostly aging males, during HIV/AIDS and COVID-19 pandemics
Animals
(June 2022)
Hart, LA , Thigpen AP, Fine AH, Gorczyca K, Willits N, Bernaldo R, Malzyner S, Guillén, D’Amato K
Cancer
Novel clonality assays for T cell lymphoma in cats targeting the T cell receptor beta, T cell receptor delta, and T cell receptor gamma loci
Journal of Veterinary Internal Medicine
(November 2021)
Radtanakatikanon A, Moore PF, Keller SM, Vernau W
T Cell immune profiles of blood and tumor in dogs diagnosed with malignant melanoma
Frontiers in Veterinary Science
(December 2021)
Sparger EE, Hong C, Ning C, Rebhun RB, Withers SS, Kieu H, Canter RJ, Monjazeb AM, Kent MS
Pre-clinical and clinical evaluation of the HYPERSCINT plastic scintillation dosimetry research platform for in vivo dosimetry during radiotherapy
Journal of Applied Clinical Medical Physics
(February 2022)
Schoepper I, Dieterich S, Trestrail EA, Kent MS
Retrospective immunohistochemical investigation of suspected non-visceral leiomyosarcoma in dogs
Journal of Veterinary Diagnostic Investigation
(March 2022)
Brady RV, Rebhun RB, Skorupski KA, Burton JH, Al-Nadaf S, Choi E, Willcox JL

Application of Bayesian regression for the identification of a catchment area for cancer cases in dogs and cats
Frontiers in Veterinary Science
(July 2022)
Díaz Cao JM, Kent MS, Rupasinghe R, Martínez-López B
Cardiology
Comparative assessment of heart rate variability obtained via ambulatory ECG and polar heart rate monitors in healthy cats: A pilot study
Frontiers in Veterinary Science
(November 2021)
Grigg EK, Ueda Y, Walker AL, Hart LA, Simas S, Stern JA
Platelet priming and activation in naturally occurring thermal burn injuries and wildfire smoke exposure is associated with intracardiac thrombosis and spontaneous echocardiographic contrast in feline survivors
Frontiers in Veterinary Science
(July 2022)
Tan AWK, Li RHL, Ueda Y, Stern JA, Hussain M, Haginoya S, Sharpe AN, Gunther-Harrington CT, Epstein SE, Nguyen N
Dentistry
Biomechanical evaluation of locking vs. non-locking 2.0-mm malleable L-miniplate fixation of simulated caudal mandibular fractures in cat
American Journal of Veterinary Research
(June 2022)
Kot CCS, Verstraete FJM, Garcia TC, Stover SM, Arzi B
The diagnostic yield of cone-beam computed tomography for degenerative changes of the temporomandibular joint in dogs
Frontiers in Veterinary Science
(August 2021)
McKay RM, Vapniarsky N, Hatcher D, Carr N, Chen S, Verstraete FJM, Cissell DD, Arzi B
Genetics
Fine-tuning p53 activity by modulating the interaction between eukaryotic translation initiation factor eIF4E and RNA-binding protein RBM38
Genes & Development
(February 2021)
Sun W, Laubach K, Lucchessi CL, Zhang Y, Chen M, Zhang J, Chen X
The effects of FGF4 retrogenes on canine morphology
Genes
(February 2022)
Bannasch D, Batcher K, Leuthard F, Bannasch M, Hug P, Marcellin-Little DJ, Dickinson PJ, Drögemüller M, Drögemüller C, Leeb T
Recent, full-length gene retrocopies are common in canids
Genome
(August 2022)
Batcher K, Varney S, York D, Blacksmith M, Kidd JM, Rebhun R, Dickinson P, Bannasch D
Infectious Disease
Serotype I and II feline coronavirus replication and gene expression patterns of feline cells—building a better understanding of serotype I FIPV biology
Viruses
(June 2022)
Cook S, Castillo D, Williams S, Haake C, Murphy B

Pharmacokinetics of isavuconazole in healthy cats after oral and intravenous administration
Journal of Veterinary Internal Medicine
(May 2022)
Woerde DJ, Wittenburg LA, Dear JD
Nutrition
Determination of mammalian deoxyribonucleic acid in commercial canine treats and supplements
Journal of American Animal Hospital Association
(April 2021)
Perez Marquez B, Larsen JA, Fascetti AJ
Spay / Neuter
An ancient practice but a new paradigm: Personal choice for the age to spay or neuter a dog
Frontiers in Veterinary Science
(March 2021)
Hart, LA, Hart BL
Stem Cell
Panobinostat effectively increases histone acetylation and alters chromatin accessibility landscape in canine embryonic fibroblasts but does not enhance cellular reprogramming
Frontiers in Veterinary Science
(September 2021)
Moshref M, Questa M, Lopez-Cervantes V, Sears TK, Greathouse RL, Crawford CK, Kol A
Surgery / Orthopedics
Comparison of 18F-sodium fluoride positron emission tomography and CT: An exploratory study in 12 dogs with elbow pain
American College of Veterinary Radiology
(January 2021)
McLarty E, Spriet M, Beylin D, Chou P, Filliquist B, Marcellin-Little DJ, Kapatkin AS
Tissue engineering of canine cartilage from surgically debrided osteochondritis dissecans fragments
Annals of Biomedical Engineering
(December 2021)
Vapniarsky N, Moncada L, Garrity C, Wong A, Filliquist B, Chou P, Kapatkin A, Marcelin-Little DJ
Long-term assessment of bone regeneration in nonunion fractures treated with compression-resistant matrix and recombinant human bone morphogenetic protein-2 in dogs
Veterinary and Comparative Orthopaedics and Traumatology
(April 2022)
Castilla A, Filliquist B, Spriet M, Garcia TC, Arzi B, Chou P, Kapatkin AS

Evaluation of transanal minimally invasive surgery for submucosal rectal resection in cadaveric canine specimens
The American College of Veterinary Surgeons
(August 2020)
Mayhew PD, Balsa IM, Guerzon CN, Gibson EA, Keel MK, Brun MV, Araya FJL
Urology
Presentation variables associated with the development of severe post-obstructive diuresis in male cats following relief of urethral obstruction
Frontiers in Veterinary Science
(April 2022)
Muller KM, Burkitt-Creedon JM, Epstein SE
2020-2021 CCAH published donor funded studies:
Canine
Cancer
Glioma-associated microglia/macrophages augment tumorigenicity in canine astrocytoma, a naturally occurring model of human glioma
Neuro-Oncology Advances (May 2021)
Toedebusch R, Grodzki AC, Dickinson PJ, Woolard K, Vinson N, Sturges B, Snyder J, Li CF, Nagasaka O, Consales B, Vernau K, Knipe M, Murthy V, Lein PJ, Toedebusch CM
Development of canine PD-1/PD-L1 specific monoclonal antibodies and amplification of canine T cell function
PLOS ONE (July 2020)
Choi JW, Withers SS, Chang H, Spanier JA, De La Trinidad VL, Panesar H, Fife BT, Sciammas R, Sparger EE, Moore PF, Kent MS, Rebhun RB, McSorley SJ
Evaluation of accuracy for 18F-FDG positron emission tomography and computed tomography for detection of lymph node metastasis in canine oral malignant melanoma
Veterinary and Comparative Oncology (August 2020)
Willcox JL, Spriet M, Zwingenberger AL, Phillips KL, Burton JH, Skorupski KA, Hansen KS, Affolter VK, Woolard KD, Beylin D, Giuffrida MA
Cardiology
Reproducibility of echocardiographic indices of left atrial size in dogs with subclinical myxomatous mitral valve disease
Journal of Veterinary Internal Medicine (June 2020)
Hsue W, Visser LC
Diabetes
Loss of sympathetic innervation to islets of Langerhans in canine diabetes and pancreatitis is not associated with insulitis
Nature Research (November 2020)
Gilor C, Pires J, Greathouse R, Horn R, Huising MO, Marks SL, Murphy B, Kol A
Nutrition
Impact of storage temperature, storage duration, and deproteinization on plasma amino acid concentrations in dogs
Research in Veterinary Science (March 2021)
Chiang C, Larsen JA, Sahtout M, Horoschak RE, Yu Z, Fascetti AJ
Surgery
A randomized controlled trial of three-dimensional versus two-dimensional imaging system on duration of surgery and mental workload for laparoscopic gastropexies in dogs
Veterinary Surgery (July 2021)
Balsa IM, Giuffrida MA, Mayhew PD
Assisting Decision-Making on Age of Neutering for Mixed Breed Dogs of Five Weight Categories: Associated Joint Disorders and Cancers
Frontiers in Veterinary Science (July 2020)
Hart BL, Hart LA, Thigpen AP, Willits NH.
Assisting Decision-Making on Age of Neutering for 35 Breeds of Dogs: Associated Joint Disorders, Cancers, and Urinary Incontinence
Frontiers in Veterinary Science (July 2020)
Hart BL, Hart LA, Thigpen AP, Willits NH
Influence of interlocking thread screws to repair simulated adult canine humeral condylar fractures
Veterinary Surgery (August 2021)
Raleigh JS, Filliquist B, Kapatkin AS, Chou PY, Marcellin-Little DJ, Garcia TC, Jacques KL, Stover SM
Percutaneous radiologically guided gastrostomy tubes: Procedural description and biomechanical comparison in a canine model
Veterinary Surgery (October 2020)
Griffin MA, Culp WTN, Garcia TC, Glaiberman CB, Giuffrida MA, Balsa IM, Mayhew PD, Johnson EG, Marks SL
Genetics
Chromatin accessibility in canine stromal cells and its implications for canine somatic cell reprogramming
Stem Cells Translational Medicine (November 2020)
Questa M, Moshref M, Jimenez RJ, Lopez-Cervantes V, Crawford CK, Settles ML, Ross PJ, Kol A
Multiple FGF4 Retrocopies Recently Derived within Canids
Genes 2020 (July 2020)
Batcher K, Dickinson P, Maciejczyk K, Brzeski K, Rasouliha SH, Letko A, Drögemüller C, Leeb T, Bannasch D
A Missense Variant in ALDH5A1 Associated with Canine Succinic Semialdehyde Dehydrogenase Deficiency (SSADHD) in the Saluki Dog
Genes 2020 (September 2020)
Vernau KM, Struys E, Letko A, Woolard KD, Aguilar M, Brown EA, Cissell DD, Dickinson PJ, Shelton GD, Broome MR, Gibson KM, Pearl PL, König F, Van Winkle TJ, O’Brien D, Roos B, Matiasek K, Jagannathan V, Drögemüller C, Mansour TA, Brown CT, Bannasch DL
Quality of DNA extracted from formalinfixed, paraffin-embedded canine tissues
Journal of Veterinary Diagnostic Investigation (July 2020)
Dear JD, Sykes JE, Bannasch DL
Liver Disease
Ferumoxytol-enhanced magnetic resonance angiography provides comparable vascular conspicuity to CT angiography in dogs with intrahepatic portosystemic shunts
Veterinary Radiology and Ultrasound (July 2021)
Wilson S, Culp WTN, Wisner ER, Cissell DD, Finn JP, Zwingenberger AL
Surgery - Orthopedics
Comparison of needle arthroscopy, traditional arthroscopy, and computed tomography for the evaluation of medial coronoid disease in the canine elbow
Veterinary Surgery (July 2021)
Hersh-Boyle RA, Chou PY, Kapatkin AS, Spriet M, Filliquist B, Garcia TC, Marcellin-Little DJ
Blood Clotting
Lipopolysaccharide-Activated Canine Platelets Upregulate High Mobility Group Box-1 via Toll-Like Receptor 4
Frontiers in Veterinary Science (June 2021)
Li RHL, Hommel C, Nguyen N.
Analgesia/Pain Control
Pharmacokinetics of a high-concentration formulation of buprenorphine (Simbadol) in male dogs
Veterinary Anaesthesia and Analgesia (July 2021)
Hansford J, Henao-Guerrero N, Machado ML, Pypendop BH
Comparison of the efficacy and duration of desensitization of oral structures following injection of a lidocaine-bupivacaine mixture via lateral percutaneous and modified infraorbital approaches in dogs
American Journal of Veterinary Research (January 2021)
Chohan AS, Pascoe PJ
Internal Medicine
Efficacy of a micronized, nanocrystal fenofibrate formulation in treatment of hyperlipidemia in dogs
Journal of Veterinary Internal Medicine (July 2021)
Munro MJL, Hulsebosch SE, Marks SL, Gilor C
Feline
Phenylpiperidine opioid effects on isoflurane minimum alveolar concentration in cats
Journal of Veterinary Pharmacology and Therapeutics (November 2020)
Brosnan RJ, Pypendop BH, Stanley SD
Reference intervals for radiographic, echocardiographic and N-terminal pro B-type natriuretic peptide values in healthy kittens
Journal of Feline Medicine and Surgery (April 2021)
Gunther-Harrington CT, Sharpe AN, Vernau KM, Ueda Y, Montgomery EA, Surmick JD, Fernandez N, Ontiveros E, Walker AL, Stern JA
Stem cell therapy prior to full-mouth tooth extraction lacks substantial clinical efficacy in cats affected by chronic gingivostomatitis
Journal of Feline Medicine and Surgery (September 2020)
Arzi B, Taechangam N, Lommer MJ, Walker NJ, Loscar MR, Borjesson DL
Stem cell therapy prior to full-mouth tooth extraction lacks substantial clinical efficacy in cats affected by chronic gingivostomatitis
Journal of Feline Medicine and Surgery (September 2020)
Arzi B, Taechangam N, Lommer MJ, Walker NJ, Loscar MR, Borjesson DL
Rabbit Carcasses for Use in Feline Diets: Amino Acid Concentrations in Fresh and Frozen Carcasses With and Without Gastrointestinal Tracts
Frontiers in Veterinary Science (January 2021)
Owens TJ, Fascetti AJ, Calvert CC, Larsen JA
Avian & Exotic Animals
Varying Expression of Mu and Kappa Opioid Receptors in Cockatiels (Nymphicus hollandicus) and Domestic Pigeons (Columba livia domestica)
Frontiers in Genetics (October 2020)
Fousse SL, Golsen BM, Sanchez-Migallon Guzman D, Paul-Murphy JR, Stern JA
Pharmacokinetics of hydromorphone hydrochloride after intramuscular and intravenous administration of a single dose to orange-winged Amazon parrots (Amazona amazonica)
American Journal of Veterinary Medicine (November 2020)
Sanchez-Migallon Guzman D, Knych, H, Douglas, J, Paul-Murphy, JR
Pharmacokinetics of amantadine after oral administration of single and multiple doses to orange-winged Amazon parrots ( Amazona amazonica)
American Journal of Veterinary Medicine (August 2020)
Berg KJ, Sanchez-Migallon Guzman D, Knych HK, Drazenovich TL, Paul-Murphy JR
Pharmacokinetic and Efficacy Study of Acyclovir Against Cyprinid Herpesvirus 3 in Cyprinus carpio
Frontiers in Veterinary Science (October 2020)
Quijano Cardé EM, Yazdi Z, Yun S, Hu R, Knych H, Imai DM, Soto E
Evaluation of the thermal antinociceptive effects of hydromorphone hydrochloride after intramuscular administration to orange-winged Amazon parrots (Amazona amazonica)
American Journal of Veterinary Medicine (October 2020)
Sanchez-Migallon Guzman D, Douglas JM, Beaufrère H, Paul-Murphy JR
2019-2020 CCAH published donor-funded studies:
Canine
Cancer
Use of transrectal ultrasonography for assessment of the size and location of prostatic carcinoma in dogs
American Journal of Veterinary Research (November 2019)
Culp, WTN, Johnson, E, Giufridda, MA, Palm, CA, Mayhew, P, Kent, MS, Rebhun, RB, Burton, JH

The interaction between RUNX2 and core binding factor beta as a potential therapeutic target in canine osteosarcoma
Veterinary and Comparative Oncology (March 2020)
Alegre, F, Ormonde, AR, Godinez, DR, Illendula, A, Bushweller, JH, Wittenburg, LA

Intramuscular diphenhydramine does not affect acute doxorubicin infusion-related arrhythmia number or severity in a prospective crossover study in canine lymphoma: A Pilot Study
Frontiers in Veterinary Science (July 2020)
Willcox, JL, Belanger, C, Burton, JH, Yu, L, Yu, U, Visser, LC, Skorupski, K, Stern, JA

Clinicopathological characteristics of histiocytic sarcoma affecting the central nervous system in dogs
Journal of Veterinary Internal Medicine (March 2020)
Toyoda, I, Vernau, W, Sturges, BK, Vermau, KM, Rossmeisl, J, Zimmerman, K, Crose, CM, Woolard, K, Gufridda, M, Higgins, RJ, Dickenson, PJ

Hematology
Canine platelets express functional Toll-like receptor-4: lipopolysaccharide-triggered platelet activation is dependent on adenosine diphosphate and thromboxane A2 in dogs
BMC Veterinary Research (July 2019)
Li, RHL, Nguyen, N, Tablin, F

Genetics
Pigment Intensity in Dogs is Associated with a Copy Number Variant Upstream of KITLG
Genes (Basel) (January 2020)
Weich, K, Affolter, V, York, D, Rebhun, R, Kallenberg, A, Bannasch, D

Surgery
Comparison of the efficacy and duration of desensitization of oral structures following injection of various volumes of a lidocaine-bupivacaine mixture via an infraorbital approach in dogs
American Journal of Veterinary Research (July 2020)
Pascoe PJ, Chohan AS.

Utility of bronchoscopy combined with surgery in the treatment and outcomes of dogs with intrathoracic disease secondary to plant awn migration
Veterinary Surgery (July 2019)
Gibson EA, Balsa IM, Mayhew PD, Phillips, K, Giuffrida, MA, Culp, WTN, Steffey, MA, Johnson, LR
Feline
Dentistry
A multicenter experience using adipose-derived mesenchymal stem cell therapy for cats with chronic, non-responsive gingivostomatitis
Stem Cell Research & Therapy (March 2020)
Arzi, B, Peralta, S, Fiani, N, Vapniarsky, N, Taechangam, N, Delatorre, U, Clark, KC, Walker, N, Loscar, M, Lommer, MJ, Fulton, M, Battig, J, Borjesson, D

Assessment of P2Y12 Inhibition by Clopidogrel in Feline Platelets Using Flow Cytometry Quantification of Vasodilator-Stimulated Phosphoprotein Phosphorylation
Frontiers in Veterinary Science (April 2020)
Li RHL, Nguyen N, Rosati T, Jandrey K

Immunology
Topology and expressed repertoire of the Felis catus T cell receptor loci
BMC Genomics (January 2020)
Radtanakatikanon A, Keller SM, Darzentas N, Moore, PF, Folch, G, Ngoune VN, Lefranc, MP, Vernau, W

Infectious Disease
Perspectives: potential therapeutic options for SARS-CoV-2 patients based on feline infectious peritonitis strategies: central nervous system invasion and drug coverage
International Journal of Antimicrobial Agents (June 2020)
Olsen, M, Cook, SE, Huang, V, Perdersen, N, Murphy, BG

Surgery
Cardiopulmonary effects of dexmedetomidine, with and without vatinoxan, in isoflurane-anesthetized cats
Veterinary Anaesthesia and Analgesia (November 2019)
Jaeger AT, Pypendop BH, Ahokoivu H, Honkavaara J

Hematology
Effects of famciclovir in cats with spontaneous acute upper respiratory tract disease
Journal of Feline Medicine and Surgery (June 2020)
Kopecny L, Maggs DJ, Leutenegger CM, Johnson LR
An RNA-directed gene editing strategy for Attenuating the infectious potential of feline immunodeficiency virus-infected cells: a proof of concept
Viruses (May 2020)
Murphy, BG, Wolf, T, Vogel, H, Castillo, D, Woolard, K
Avian, Reptile & Other Companion Animals
Gastrointestinal
Pharmacokinetics of maropitant citrate in New Zealand White rabbits ( Oryctolagus cuniculus)
American Journal of Veterinary Research, (October 2019)
Ozawa, SM, Hawkins, MG, Drazenovich, TL, Kass, PH, Knych, K

Cancer
Evaluation of deslorelin implant on subsequent mammary tumors of rats (Rattus norvegicus)
Journal of Exotic Pet Medicine (October 2019)
Vergneau-Grosset, C, Peña, L, Cluzel, C, Hawkins, MG, Maccolini, E, Sinclair, K, Graham, J, Sadar, MJ, Guzman, DS-M, Lair, S, Langlois, I, Paul-Murphy, J

Infectious Disease
The formation, persistence, and resistance to disinfectant of the Erysipelothrix piscisicarius biofilm
Journal of Aquatic Animal Health (January 2020)
Pomaranski, E, Soto, E

Non-lethal diagnostic methods for koi herpesvirus in koi Cyprinus carpio
Diseases of Aquatic Organisms (March 2020)
Soto, E, Tamez-Trevino, E, Yarzdi, Z, Stevens, BN, Yun, S, Martinez-Lopez, B, Burges, J

Surgery
Evaluation of a ventral and a left lateral approach to coelioscopy in bearded dragons ( Pogona vitticeps)
American Journal of Veterinary Research, (March 2020)
Frei, S, Guzman, DS-M, Kass, PH, Giuffrida, MA, Mayhew, PD
2018-2019 CCAH published donor-funded studies
Cancer
Investigation of immune cell markers in feline oral squamous cell carcinoma
Veterinary Immunology and Immunopathology (Feb. 2019)
Sparger EE, Murphy BG, Kamal FM, Arzi B, Naydan D, Skouritakis K, Cox DP, Skorupski K.

Association of macrophage and lymphocyte infiltration with outcome in canine osteosarcoma
Veterinary and Comparative Oncology (Mar. 2019)
Withers SS, Skorupski KA, York D, Choi JW, Woolard KD, Laufer-Amorim R, Sparger EE, Rodriguez CO, McSorley SJ, Monjazeb AM, Murphy WJ, Canter
RJ, Rebhun RB

Cardiology
Cardiac effects of a single dose of pimobendan in cats with hypertrophic cardiomyopathy; a randomized, placebo-controlled, crossover study
Frontiers in Veterinary Science (Feb. 2019)
Oldach MS, Ueda Y, Ontiveros ES, Fousse SL, Harris SP, Stern JA

Echocardiographic evaluation of velocity ratio, velocity time integral ratio, and pulmonary valve area in dogs with pulmonary valve stenosis
Journal of Veterinary Internal Medicine (Sep. 2018)
Nishimura S, Visser LC, Bélanger C, Oldach MS, Gunther-Harrington CT, Stern JA

Emergency Medicine
Efficacy of manual ventilation techniques during cardiopulmonary resuscitation in dogs
Frontiers in Veterinary Science (Oct. 2018)
Hopper K, Rezende ML, Borchers A, Epstein SE

Genetics
Genetic heterogeneity and diversity of North American golden retrievers using a low density STR marker pane
PLOS One (Feb.2019)
Ontiveros ES, Hughes S, Penedo MCT, Grahn RA, Stern JA

Genetics-Ophthalmology
Evaluation of the major histocompatibility complex (MHC) class II as a candidate for sudden acquired retinal degeneration syndrome (SARDS) in dachshunds
Veterinary Ophthalmology (Feb. 2019)
Stromberg SJ, Thomasy SM, Marangakis AD, Kim S, Cooper AE, Brown EA, Maggs DJ, Bannasch DL

Hematology
Influence of needle gauge used for venipuncture on measures of hemostasis in cats
Journal of Feline Medicine Surgery (Feb. 2019)
Solbak S, Epstein SE, Hopper K

Immunology
Multi-color flow cytometry for evaluating age-related changes in memory lymphocyte subsets in dogs
Development & Comparative Immunology (Oct. 2018)
Withers SS, Moore PF, Chang H, Choi JW, McSorley SJ, Kent MS, Monjazeb AM, Canter RJ, Murphy WJ, Sparger EE, Rebhun RB

Infectious Disease
Pilot study of the safety and solerability of asubconjunctival penciclovir implant in cats experimentally infected with herpesvirus
Journal of Ocular Pharmacology and Therapeutics (Jan/Feb 2019)
Covert JC, Thomasy SM, Kado-Fong H, Kon LN, Kass PH, Reilly CM, Lappin MR, Margulies BJ, Maggs DJ

Babesia conradae infection in coyote hunting dogs infected with multiple blood-borne pathogens
Journal of Veterinary Internal Medicine (Sep. 2018)
Dear JD, Owens SD, Lindsay LL, Biondo AW, Chomel BB, Marcondes M, Sykes JE

Neurology
Intracranial pressure monitoring in normal dogs usingsubdural and intraparenchymal miniature strain-gauge transducers
Journal of Veterinary Internal Medicine (Mar 2019)
Sturges BK, Dickinson PJ, Tripp LD, Udaltsova I, LeCouteur RA

Pharmacokinetics and safety of zonisamide after oral administration of single and multiple doses to Hispaniolan Amazon parrots
American Journal of Veterinary Research (Feb. 2019)
Keller KA, Guzman DS, Boothe DM, Visser M, de Matos RE, Petritz OA, Kass PH, Paul-Murphy JR

Nutrition
Determination of total mercury and methylmercury concentrations in commercial canine diets
Topics in Companion Animal Medicine (June 2019)
Sires RA, Fascetti AJ, Puschner B, Larsen JA

Pain Management
Evaluation of the thermal antinociceptive effects and pharmacokinetics after intramuscular administration of buprenorphine hydrochloride to cockatiels (Nymphicus hollandicus)
American Journal of Veterinary Research (Dec. 2018)
Guzman DS, Houck EL, Knych HKD, Beaufrère H, Paul-Murphy JR

Surgery
Surgery cardiorespiratory effects of variable pressure thoracic insufflation in cats undergoing video-assisted thoracic surgery
Veterinary Surgery (Jun. 2019)
Mayhew PD, Pascoe PJ, Giuffrida MA, Mitchell J, Steffey MA, Culp WTN

Effects of hole diameter on torsional mechanical properties of the rabbit femur
Veterinary and Comparative Orthopaedics and Traumatology (Jan. 2019)
Massie AM, Kapatkin AS, Garcia TC, Guzman DS, Chou PY, Stover SM

Faculty Research and Program Support

Faculty Research and Program Support