Faculty Research and Program Support

Faculty Research and Program Support

The CCAH provides grant funding on a competitive basis to faculty for studies dedicated to advancing the health of dogs, cats and exotic pets. For over 30 years the CCAH has been supporting these efforts, and has awarded more than $24 million. In 2024-2025, the CCAH provided $1,592,035 in faculty research support.

• Safety and efficacy of a STAT3-targeted cyclic oligonucleotide: From murine models to a phase 1 clinical trial in pet cats with oral cancer
• Grandis JR, Skorupski KA, Cheng N, Cui Z, Li H, Woerner LC, Gencel-Augusto J, Zeng Y, Shiah JV, Bhola NE, Sen M, Blum K, Kim M, York D, Rebhun RB, Chang H, Murad NF, Olshen AB, Sparger EE, Johnson DE
  
  The goal of this study was to test a new kind of medicine designed to block a cancer‑promoting protein called STAT3. Because STAT3 helps tumors grow and also weakens the immune system's ability to fight cancer, shutting it down could be very helpful, but it's been very hard to target with drugs. Researchers created a new, more stable version of a STAT3‑blocking molecule, called a cyclic STAT3 decoy (CS3D), and wanted to find out: Does this new drug shrink tumors and improve the immune response in mouse models of head and neck cancer? Is it safe and effective in real-world animals (pet cats) that naturally develop the same type of cancer? Are there immune system differences between animals that respond well to the drug and those that don’t? The results showed that some animals did respond, and these responders had meaningful immune changes in their blood and tumors, supporting the idea that this drug should be tested next in human patients with head and neck cancer.
   
• Fatty Acid Analysis and Stability of Selected Edible Oils Used in Homemade Pet Diets
• Larsen JA, Stockman J, Li X, Wang SC
  
  This study aimed to evaluate the fatty acid composition and oxidative stability of commonly used edible oils intended for home‑prepared pet diets. Specifically, the objectives were to (1) compare measured fatty acid profiles with database values and (2) assess how recommended storage conditions affect oxidative quality over time. Fourteen oil products across seven oil types were purchased and stored per manufacturer instructions. Fatty acid profiles were analyzed at baseline and 12 months, while free fatty acidity, peroxide value, and induction time were measured at baseline, 6 months, and 12 months. Results showed that linoleic acid levels were generally higher than USDA FNDDS values, except in several sunflower and safflower oils. Most oils demonstrated significant oxidative degradation over time, with increased peroxide values and reduced induction times. The findings suggest that sunflower and safflower oils may be unreliable sources of linoleic acid, and that cold storage more effectively preserves oil quality. Careful oil selection and refrigeration are recommended to ensure nutritional adequacy and prevent oxidation in home‑prepared pet diets.
• Ocular tolerance and tear film pharmacokinetics of 1% penciclovir cream in cats
• Pe'er O, Thomasy SM, Feuer E, Knych HK, Ofri R, Sebbag L
  This study aimed to assess the ocular tolerance and tear‑film pharmacokinetics of a 1% penciclovir cream (Fenlips®), a dermatologic formulation repurposed for topical treatment of feline herpesvirus type 1 (FHV‑1) ocular disease. Owner surveys indicated strong clinical acceptance, with most reporting no adverse effects and rating the treatment as effective. To further evaluate safety, a 10‑day prospective study in healthy cats compared Fenlips® with artificial tears and found no significant differences in ocular surface parameters, aside from a mild increase in corneal sensitivity in treated eyes. A second prospective study demonstrated that penciclovir concentrations in the tear film remained above the inhibitory threshold for FHV‑1 for over 8 hours, with an extended terminal half‑life. Overall, Fenlips® was well tolerated and achieved therapeutically relevant tear‑film levels, supporting its potential use as a twice‑daily topical antiviral therapy for herpetic keratoconjunctivitis in cats.

2024-2025 CCAH published donor funded studies:

Aging

A non-randomized pilot study to test the feasibility of developing a frailty scale for pet cats
Frontiers in Veterinary Science
(February 2025)
Colleran EJ, Delgado MM, Ren Y, German AJ, Gruen ME, Gunn-Moore DA, Romanowski K, Simpson W, Kirnos C, Ternes KK, Karnia J, Temples M, Taylor SL, Bain M, Buffington CAT

Anesthesia

Increasing plasma ketamine concentrations decrease the minimum alveolar concentration of isoflurane in rabbits
Frontiers in Veterinary Science
(June 2025)
Barter LS, Pypendop BH

Target-controlled infusions of butorphanol worsen hemodynamics in isoflurane-anesthetized cats
Frontiers in Veterinary Science
(June 2025)
Pypendop BH, Cenani A, Machado ML, Barter LS

Ultrasound-guided trigeminal nerve approach at the level of the terygopalatine fossa in cat cadavers
Veterinary Anaesthesia and Analgesia 
(November-December 2024)
Fernandez Barrientos MA, Cenani A, Brown CS, Arzi B, Wolfs E, Pypendop BH

Cancer

Artificial intelligence-based quantification of lymphocytes in feline small intestinal biopsies
Veterinary Pathology
(March 2025)
Wulcan JM, Giaretta PR, Fingerhood S, de Brot S, Crouch EEV, Wolf T, Casanova MI, Ruivo PR, Bolfa P, Streitenberger N, Bertram CA, Donovan TA, Keel MK, Moore PF, Keller SM

Safety and efficacy of a STAT3-targeted cyclic oligonucleotide: From murine models to a phase 1 clinical trial in pet cats with oral cancer
Cancer Cell
(August 2025)
Grandis JR, Skorupski KA, Cheng N, Cui Z, Li H, Woerner LC, Gencel-Augusto J, Zeng Y, Shiah JV, Bhola NE, Sen M, Blum K, Kim MO, York D, Rebhun RB, Chang H, Murad NF, Olshen AB, Sparger EE, Johnson DE

Do pre-treatment biopsy characteristics predict early tumour progression in feline diffuse large B cell nasal lymphoma treated with radiotherapy?
Veterinary and Comparative Oncology
(March 2025)
Poirier VJ, Meier V, Turek M, Christensen N, Bowal J, Ponzini MD, Keller SM

Effect of glyceryl trinitrate and clevidipine administration on CT angiogram findings in dogs undergoing prostatic artery embolization for prostatic carcinoma
PLOS ONE
(December 2024)
Veluvolu S, Willcox JL, Skorupski KA, Al-Nadaf S, Rebhun R, Wittenburg L

Dentistry

Preliminary characterisation of immune cell populations in the oral mucosa of a small cohort of healthy dogs (Canis lupus familiaris)
Anatomia, Histologia, Embryologia
(November 2024)
Soltero-Rivera M, Bailey M, Blandino A, Arzi B, Vapniarsky N

Impact of pro-inflammatory cytokine preconditioning on metabolism and extracellular vesicles in feline mesenchymal stromal cells: a preliminary study
Stem Cells
(June 2025)
Soltero-Rivera M, Arzi B, Bourebaba L, Marycz K

Infectious Disease

Mesenchymal stem/stromal cell therapy improves immune recovery in a feline model of severe coronavirus infection
Stem Cells Translational Medicine
(June 2025)
Wanakumjorn P, Kimura K, Castillo D, McLarty E, Formaker R, Qiao R, Farrell K, Brostoff T, Ramarapu R, Pires J, Cohen-Davidyan T, Cassano J, Murphy B, Reagan K, Kol A

The nucleoside analog GS-441524 effectively attenuates the In vitro replication of multiple lineages of circulating canine distemper viruses isolated from wild North American carnivores
Viruses
(January 2025)
Oliver-Guimera A, Murphy BG, Keel MK

Doxycycline with or without famciclovir for infectious ophthalmic and respiratory disease: a prospective, randomized, masked, placebo-controlled trial in 373 kittens
Journal of Feline Medicine and Surgery
(November 2024)
Vernau KM, Kim S, Thomasy SM, Lucyshyn DR, Purpura J, Montgomery E, Surmick JD, Dubelko AR, Moussavi A, Kass PH, Maggs DJ

Open label clinical trial of orally administered molnupiravir as a first-line treatment for naturally occurring effusive feline infectious peritonitis
Journal of Veterinary Internal Medicine
(November-December 2024)
Reagan KL, Brostoff T, Pires J, Rose A, Castillo D, Murphy BG

Immunology

Single cell RNA-sequencing of feline peripheral immune cells with V(D)J repertoire and cross species analysis of T lymphocytes
Frontiers in Immunology
(November 2024)
Ramarapu R, Wulcan JM, Chang H, Moore PF, Vernau W, Keller SM

Internal Medicine

Trace element content is associated with urolith type in goats and pigs diagnosed with urolithiasis
American Journal of Veterinary Research
(April 2025)
Chigerwe M, Killilea DW, Hardgrove CN, Mann U, Stoller ML, Westropp JL

Effects of plasma and hetastarch administration on colloid oncotic pressure and coagulation parameters in dairy calves and goats
Journal of Veterinary Internal Medicine
(May-June 2025)
Cuneo SW, Abi-Nader BA, Blasczynski SJ, Chigerwe M

Nutrition

Fatty acid analysis and stability of selected edible oils used in homemade pet diets
Journal of Veterinary Internal Medicine
(May 2025)
Larsen JA, Stockman J, Li X, Wang SC

Diurnal variation of serum phosphorus concentrations in intact male adult domestic cats
Journal of Veterinary Internal Medicine
(November-December 2024)
Chiang CF, Vanderstichel R, Stockman J, Larsen JA, Fascetti AJ

Ophthalmology

Ocular tolerance and tear film pharmacokinetics of 1 % penciclovir cream in cats 
Research in Veterinary Science
(September 2025)
Pe'er O, Thomasy SM, Feuer E, Knych HK, Ofri R, Sebbag L

Pain

Pharmacokinetics of single-dose oral acetaminophen with and without concurrent administration of silymarin or N-acetylcysteine in orange-winged Amazon parrots (Amazona amazonica)
American Journal of Veterinary Research
(March 2025)
Megan L, Sanchez-Migallon Guzman D, Knych H, Beaufrère HH

Surgery / Orthopedics

Subclinical gastrointestinal mucosal lesions occur in dogs with intrahepatic portosystemic shunts independent of percutaneous transvenous coil embolization
Journal of the American Veterinary Medical Association 
(February 2025)
Gibson EA, Culp WTN, Hardy BT, Giuffrida MA, Balsa IM, Mayhew P, Marks SL

Radiographs acquired before total hip replacement in dogs underestimate femoral canal flare and misjudge trochanteric overhang
American Journal of Veterinary Research
(April 2025)
Bae S, Marcellin-Little DJ, Pritikin R, Garcia TC

Patient-specific 3D-printed nasopharyngeal stents in dogs: a cadaveric pilot study
Frontiers in Veterinary Science
(November 2024)
Sutter C, Hardy B, Lucero S, Johnson L, Culp W

Prior Publications

• 2024-2025 CCAH published donor funded studies:

• Aging

  A non-randomized pilot study to test the feasibility of developing a frailty scale for pet cats
  Frontiers in Veterinary Science
  (February 2025)
  Colleran EJ, Delgado MM, Ren Y, German AJ, Gruen ME, Gunn-Moore DA, Romanowski K, Simpson W, Kirnos C, Ternes KK, Karnia J, Temples M, Taylor SL, Bain M, Buffington CAT

  Anesthesia

  Increasing plasma ketamine concentrations decrease the minimum alveolar concentration of isoflurane in rabbits
  Frontiers in Veterinary Science
  (June 2025)
  Pypendop BH, Cenani A, Machado ML, Barter LS

  Target-controlled infusions of butorphanol worsen hemodynamics in isoflurane-anesthetized cats
  Frontiers in Veterinary Science
  (February 2025)
  Colleran EJ, Delgado MM, Ren Y, German AJ, Gruen ME, Gunn-Moore DA, Romanowski K, Simpson W, Kirnos C, Ternes KK, Karnia J, Temples M, Taylor SL, Bain M, Buffington CAT

  Ultrasound-guided trigeminal nerve approach at the level of the terygopalatine fossa in cat cadavers
  Veterinary Anaesthesia and Analgesia 
  (November-December 2024)
  Fernandez Barrientos MA, Cenani A, Brown CS, Arzi B, Wolfs E, Pypendop BH

  Cancer

  Artificial intelligence-based quantification of lymphocytes in feline small intestinal biopsies
  Veterinary Pathology
  (March 2025)
  Wulcan JM, Giaretta PR, Fingerhood S, de Brot S, Crouch EEV, Wolf T, Casanova MI, Ruivo PR, Bolfa P, Streitenberger N, Bertram CA, Donovan TA, Keel MK, Moore PF, Keller SM

  Safety and efficacy of a STAT3-targeted cyclic oligonucleotide: From murine models to a phase 1 clinical trial in pet cats with oral cancer
  Cancer Cell
  (August 2025)
  Grandis JR, Skorupski KA, Cheng N, Cui Z, Li H, Woerner LC, Gencel-Augusto J, Zeng Y, Shiah JV, Bhola NE, Sen M, Blum K, Kim MO, York D, Rebhun RB, Chang H, Murad NF, Olshen AB, Sparger EE, Johnson DE

  Do pre-treatment biopsy characteristics predict early tumour progression in feline diffuse large B cell nasal lymphoma treated with radiotherapy?
  Veterinary and Comparative Oncology
  (March 2025)
  Poirier VJ, Meier V, Turek M, Christensen N, Bowal J, Ponzini MD, Keller SM

  Effect of glyceryl trinitrate and clevidipine administration on CT angiogram findings in dogs undergoing prostatic artery embolization for prostatic carcinoma
  PLOS ONE
  (December 2024)
  Veluvolu S, Willcox JL, Skorupski KA, Al-Nadaf S, Rebhun R, Wittenburg L

  Dentistry

  Preliminary characterisation of immune cell populations in the oral mucosa of a small cohort of healthy dogs (Canis lupus familiaris)
  Anatomia, Histologia, Embryologia
  (November 2024)
  Soltero-Rivera M, Bailey M, Blandino A, Arzi B, Vapniarsky N

  Impact of pro-inflammatory cytokine preconditioning on metabolism and extracellular vesicles in feline mesenchymal stromal cells: a preliminary study
  Stem Cells
  (June 2025)
  Soltero-Rivera M, Arzi B, Bourebaba L, Marycz K

  Infectious Disease

  Mesenchymal stem/stromal cell therapy improves immune recovery in a feline model of severe coronavirus infection
  Stem Cells Translational Medicine
  (June 2025)
  Wanakumjorn P, Kimura K, Castillo D, McLarty E, Formaker R, Qiao R, Farrell K, Brostoff T, Ramarapu R, Pires J, Cohen-Davidyan T, Cassano J, Murphy B, Reagan K, Kol A

  The nucleoside analog GS-441524 effectively attenuates the In vitro replication of multiple lineages of circulating canine distemper viruses isolated from wild North American carnivores
  Viruses
  (January 2025)
  Oliver-Guimera A, Murphy BG, Keel MK

  Doxycycline with or without famciclovir for infectious ophthalmic and respiratory disease: a prospective, randomized, masked, placebo-controlled trial in 373 kittens
  Journal of Feline Medicine and Surgery
  (November 2024)
  Vernau KM, Kim S, Thomasy SM, Lucyshyn DR, Purpura J, Montgomery E, Surmick JD, Dubelko AR, Moussavi A, Kass PH, Maggs DJ

  Open label clinical trial of orally administered molnupiravir as a first-line treatment for naturally occurring effusive feline infectious peritonitis
  Journal of Veterinary Internal Medicine
  (November-December 2024)
  Reagan KL, Brostoff T, Pires J, Rose A, Castillo D, Murphy BG

  Immunology

  Single cell RNA-sequencing of feline peripheral immune cells with V(D)J repertoire and cross species analysis of T lymphocytes
  Frontiers in Immunology
  (November 2024)
  Ramarapu R, Wulcan JM, Chang H, Moore PF, Vernau W, Keller SM

  Internal Medicine

  Trace element content is associated with urolith type in goats and pigs diagnosed with urolithiasis
  American Journal of Veterinary Research
  (April 2025)
  Chigerwe M, Killilea DW, Hardgrove CN, Mann U, Stoller ML, Westropp JL

  Effects of plasma and hetastarch administration on colloid oncotic pressure and coagulation parameters in dairy calves and goats
  Journal of Veterinary Internal Medicine
  (May-June 2025)
  Cuneo SW, Abi-Nader BA, Blasczynski SJ, Chigerwe M

  Nutrition

  Fatty acid analysis and stability of selected edible oils used in homemade pet diets
  Journal of Veterinary Internal Medicine
  (May 2025)
  Larsen JA, Stockman J, Li X, Wang SC

  Diurnal variation of serum phosphorus concentrations in intact male adult domestic cats
  Journal of Veterinary Internal Medicine
  (November-December 2024)
  Chiang CF, Vanderstichel R, Stockman J, Larsen JA, Fascetti AJ

  Ophthalmology

  Ocular tolerance and tear film pharmacokinetics of 1 % penciclovir cream in cats 
  Research in Veterinary Science
  (September 2025)
  Pe'er O, Thomasy SM, Feuer E, Knych HK, Ofri R, Sebbag L

  Pain

  Pharmacokinetics of single-dose oral acetaminophen with and without concurrent administration of silymarin or N-acetylcysteine in orange-winged Amazon parrots (Amazona amazonica)
  American Journal of Veterinary Research
  (March 2025)
  Megan L, Sanchez-Migallon Guzman D, Knych H, Beaufrère HH

  Surgery / Orthopedics

  Subclinical gastrointestinal mucosal lesions occur in dogs with intrahepatic portosystemic shunts independent of percutaneous transvenous coil embolization
  Journal of the American Veterinary Medical Association 
  (February 2025)
  Gibson EA, Culp WTN, Hardy BT, Giuffrida MA, Balsa IM, Mayhew P, Marks SL

  Radiographs acquired before total hip replacement in dogs underestimate femoral canal flare and misjudge trochanteric overhang
  American Journal of Veterinary Research
  (April 2025)
  Bae S, Marcellin-Little DJ, Pritikin R, Garcia TC

  Patient-specific 3D-printed nasopharyngeal stents in dogs: a cadaveric pilot study
  Frontiers in Veterinary Science
  (November 2024)
  Sutter C, Hardy B, Lucero S, Johnson L, Culp W

• 2023-2024 CCAH published donor funded studies:

• Anesthesia

  Correlation, agreement and concordance of cardiac output estimated by transthoracic ultrasound and transesophageal Doppler with pulmonary artery thermodilution in anesthetized cats
  Veterinary Anaesthesia and Analgesia
  (November 2024)
  Pypendop BH, Rivas VN, Bueno MC, Chohan AS, Barter LS, Stern JA
  
  Effects of trazodone and dexmedetomidine on fentanyl-mediated reduction of isoflurane minimum alveolar concentration in cats
  Veterinary Anaesthesia and Analgesia
  (January 2024)
  Brosnan RJ, Pypendop BH, Cenani A
   

  Cancer

  Development of a flow cytometric panel to assess prognostic biomarkers in fine needle aspirates of canine cutaneous or subcutaneous mast cell tumors
  Frontiers in Veterinary Science
  (November 2023)
  Wu BX, Lejeune A, Affolter VK, Iamone G, Riondato F, Kol A
  
  Isoform-specific disruption of the TP73 gene reveals a critical role for TAp73γ in tumorigenesis via leptin
  eLife
  (August 2023)
  Kong X , Yan W, Sun W, Zhang Y, Yang HJ, Chen M, Chen H, de Vere White RW, Zhang J, Chen X 

  TP73 Isoform-specific disruption reveals a critical role of TAp73beta in growth suppression and inflammatory response
  CDDpress
  (January 2023)
  Zhang J, Sun W, Yan W, Kong X, Shen T, Laubach K, Chen M, Chen X

  Cardiology

  Evaluation of clopidogrel response in healthy cats using a novel viscoelastic test and thromboelastography
  Frontiers in Veterinary Science
  (June 2024)
  Rosati T, Jandrey KE, Stern JA, Nguyen N, Li RHL

  Platelet hyperresponsiveness and increased platelet-neutrophil aggregates in dogs with myxomatous mitral valve disease and pulmonary hypertension
  Journal of Veterinary Internal Medicine
  (May 2024)
  Duler L, Visser  L, Nguyen N, Johnson LR, Stern JA, Li RHL

  Genetics

  Naturally occurring canine laminopathy leading to a dilated and fibrosing cardiomyopathy in the Nova Scotia Duck Tolling Retriever
  Scientific Reports 
  (November 2023)
  Bannasch DL, Oertle DT, Vo J, Batcher KL, Stern JA, Kaplan JL, Li RHL, Madden IE, Christen M, Leeb T, Joshi N

  Association of the FGF4L2 retrogene with fibrocartilaginous embolic myelopathy in dogs
  Journal of Veterinary Internal Medicine
  (November 2023)
  Embersics C, Bannasch D, Batcher K, Boudreau EC, Church M, Miller A, Platt S, Koehler J, Olby N, Rossmeisl J, Rissi D, Grahn R, Donner J, Dickinson PJ

  Infectious Disease

  Feline Infectious Peritonitis mRNA vaccine elicits both humoral and cellular immune responses in mice
  Vaccines
  (June 2024)
  Brostoff T, Savage HP, Jackson KA, Dutra JC, Fontaine JH, Hartigan-O’Connor DJ, Carney RP, Pesavento PA

  Serologic, virologic and pathologic features of cats with naturally occurring Feline Infectious Peritonitis enrolled in antiviral clinical trials
  Viruses
  (March 2024)
  Murphy BG, Castillo D, Neely NE, Kol A, Brostoff T, Grant CK, Reagan KL

  Prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and feline enteric coronavirus (FECV) in shelter-housed cats in the Central Valley of California, USA
  VetRecord
  (September 2023)
  Chen D, López-Pérez AM, Vernau KM, Maggs DJ, KimS, Foley J

  The late asymptomatic and terminal immunodeficiency phases in experimentally FIV-infected cats—A long-term study
  Viruses
  (August 2023)
  Murphy BG, Castillo D, Cook S, Eckstrand C, Evans S, Sparger E, Grant CK

  Nutrition

  Exploring the impact of age, and body condition score on erythrocytic B1-Dependent transketolase activity in cats: A comprehensive analysis of thiamine status
  Heliyon
  (July 2024)
  Fascetti AJ, Larsen JA, Min A, Nair M, Montano M, Giulivi C

  Factors influencing vitamin B6 status in domestic cats: age, disease, and body condition score
  Scientific Reports 
  (January 2024)
  Chu V, Fascetti AJ, Larsen JA, Montano M, Giulivi C

  Pharmacokinetics

  Pharmacokinetics of single-dose oral atorvastatin and its metabolites support therapeutic use in orange-winged Amazon parrots (Amazona amazonica)
  American Journal of Veterinary Research
  (December 2023)
  Mikoni N, Guzman DSM, Knych H, Beaufrère H

  Renal

  A lentivirus-vectored feline erythropoietin gene therapy strategy in tissue culture and rodent models for the potential treatment of chronic renal disease-associated anemia
  American Journal of Veterinary Research
  (April 2024)
  Cook SE, Castillo D, Wolf T, Hillman C, Bauer K, Williams S, Murphy BG

  Regenerative Medicine

  Distinctive characteristics of extracellular vesicles from feline adipose and placenta stromal cells unveil potential for regenerative medicine in cats
  Journal of the American Veterinary Medical Association
  (March 2024)
  Soltero-Rivera M, Arzi B, Bourebaba L, Marycz K

  Spay / Neuter 

  Assisting decision-making on age of neutering for German Short/Wirehaired Pointer, Mastiff, Newfoundland, Rhodesian Ridgeback, Siberian Husky: associated joint disorders, cancers, and urinary incontinence
  Frontiers in Veterinary Science
  (April 2024)
  Hart LA, Thigpen AP, Hart BL, Willits NH, Lee M, Babchuk MM, Lee J, Ho M, Clarkson ST, Chou JW 

   

  Surgery / Orthopedics

  K-wire is more damaging than standard or acrylic drill bits when evaluating torsional properties of rabbit (Oryctolagus cuniculi) femurs
  American Journal of Veterinary Research
  (June 2024)
  Massie AM, Kapatkin AS, Garcia TC, Marcellin-Little DJ, Guzman DSM, Chou PY, Stover SM

  Evaluation of mediastinoscopy for cranial mediastinal and tracheobronchial lymphadenectomy in canine cadavers
  Veterinary Surgery
  (April 2024)
  Gibson EA, Brust K, Steffey MA

  Kinematic performance of a novel temporomandibular joint replacement prosthesis under bite-force conditions in dogs and cats
  American Journal of Veterinary Research
  (March 2024)
  Weed M, Garcia TC, Goldschmidt SL, Marcellin-Little DJ

  Computed tomographic lymphangiography following percutaneous intrahepatic injection of iopamidol in cats
  American Journal of Veterinary Research
  (January 2023)
  Johnson EG, Mayhew PD, Runge JL

• 2022-2023 CCAH published donor funded studies:

• Anesthesia

  Pharmacokinetics of buprenorphine and its metabolite norbuprenorphine in neutered male cats anesthetized with isoflurane
  Veterinary Anaesthesia and Analgesia
  (July 2023)
  Pypendop BH, Stoddard S, Barter LS
  
  Effects of dopamine, norepinephrine or phenylephrine on the prevention of hypotension in isoflurane-anesthetized cats administered vatinoxan or vatinoxan and dexmedetomidine
  Veterinary Anaesthesia and Analgesia
  (January 2022)
  Kobluk K, Pypendop BH
   

  Cancer

  A variant in the 5′UTR of ERBB4 is associated with lifespan in Golden Retrievers
  Geroscience
  (October 2023)
  Rebhun RB, York D, De Graaf FMD, Yoon P, Batcher KL, Luker ME, Ryan S, Peyton J, Kent MS, Stern JA, Bannasch DL
  
  Changes in diet and supplement use in dogs with cancer
  Journal of Veterinary Internal Medicine
  (August 2023)
  Kramer ML, Larsen JA, Kent MS

  Intra- and Intertumoral Microglia/Macrophage Infiltration and Their Associated Molecular Signature Is Highly Variable in Canine Oligodendroglioma: A Preliminary Evaluation
  Veterinary Sciences
  (June 2023)
  Grigg EK, Liu S, Dempsey DG, Wong K, Bain M, Sollers JJ, Haddock R, Kogan LR, Barnhard JA, Tringali AA, Thigpen AP, Hart, LA

  Fractionated oral dosing and its effect on cyclophosphamide pharmacokinetics in dogs with high-grade multicentric lymphoma
  Veterinary and Comparative Oncology
  (March 2023)
  Veluvolu S, Willcox JL, Skorupski KA, Al-Nadaf S, Rebhun R, Wittenburg L

  Longevity and mortality in cats: A single institution necropsy study of 3108 cases (1989-2019)
  PLOS ONE
  (December 2022)
  Kent MS, Karchemskiy S, Culp WTN, Lejeune AT, Pesavento PA, Toedebusch C, Brady R, Rebhun R

  Fluid Therapy

  Continuous fluid infusion per rectum compared with intravenous fluid infusion in pigs
  Journal of Veterinary Internal Medicine
  (August 2023)
  Chigerwe M, Blasczynski SJ, Abi-Nader BA, Condy PM, Kretsch CM, Depenbrock SM

  Genetics

  FGF4L2 retrogene copy number is associated with intervertebral disc calcification and vertebral geometry in Nova Scotia Duck Tolling Retrievers
  American Journal of Veterinary Research
  (January 2023)
  Bianchi CA, Marcellin-Little DJ, Dickinson PJ, Garcia TC, Li CF, Batcher K, Bannasch DL

  Infectious Disease

  Clinical assessment of a point-of-care assay to determine protective vaccinal antibody titers to canine viral diseases
  The Veterinary Journal
  (September 2023)
  Ad Y, Halperin IM, Olstad EC, Gershwin LJ, Sullivan L, Reagan KL

  Efficacy of oral Remdesivir compared to GS-441524 for treatment of cats with naturally occurring effusive Feline Infectious Peritonitis: A blinded, non-inferiority study
  Viruses
  (August 2023)
  Cosaro E, Pires J, Castillo D, Murphy BG, Reagan KL

  Characteristics of extended-spectrum β-lactamase producing enterobacterales isolated from dogs and cats, 2011-2021
  Veterinary Sciences
  (February 2023)
  Woerde DJ, Reagan KL, Byrne BA, Weimer BC, Epstein SE, Schlesener C, Huang BC, Sykes JE

  Tyzzer disease in 19 preweaned orphaned kittens
  Journal of Veterinary Diagnostic Investigation
  (March 2023)
  Fingerhood S, Mendonca FS, Uzal FA, Marks SL, Vernau KM, Navarro MA, Choi EA
  
  An optimized bioassay for screening combined anticoronaviral compounds for efficacy against Feline Infectious Peritonitis virus with pharmacokinetic analyses of GS-441524, Remdesivir, and Molnupiravir in cats
  Viruses
  (May 2022)
  Cook S, Wittenburg L, Yan VC, Theil JH, Castillo D, Reagan KL, Williams S, Pham CD, Li C, Muller FL, Murphy BG

  Efficacy of a multidose acyclovir protocol against cyprinid herpesvirus 3 infection in koi (Cyprinus carpio)
  American Journal of Veterinary Research
  (November 2022)
  Sosa-Higareda M, Yazdi Z, Littman EM, Quijano Carde EM, Yun S, Soto E

  Neurology

  Oral cytarabine ocfosfate pharmacokinetics and assessment of leukocyte biomarkers in normal dogs
  Journal of Veterinary Internal Medicine
  (September 2023)
  Zwueste DM, Vernau KM, Vernau W, Pypendop BH, Knych HK, Rodrigues CA, Kol A, Questa M, Dickinson PJ

  Tolerability and pharmacokinetics of intravenous allopregnanolone with and without midazolam pretreatment in two healthy dogs
  Epilepsia Open
  (January 2023)
  Bruun DA, MA B, Chen YJ, Wu CY, Aleman M, Zolkowska D, Smiley-Jewell SM, Rogawski MA, Lein PJ

  Ophthalmology

  Symblepharon in kittens: a retrospective study of 40 kittens and 54 eyes (2002-2022)
  Journal of Feline Medicine and Surgery
  (February 2023)
  Bruun DA, MA B, Chen YJ, Wu CY, Aleman M, Zolkowska D, Smiley-Jewell SM, Rogawski MA, Lein PJ

  The TGM2 inhibitor cysteamine hydrochloride does not impact corneal epithelial and stromal wound healing in vitro and in vivo
  Experimental Eye Research
  (January 2023)
  Minella AL, Casanova MI, Chokshi TJ, Kang J, Cosert K, Gragg MM, Bowman MA, Mccorkell ME, Daley NL, Leonard BC, Murphy CJ, Raghunathan VK, Thomasy SM

  Ocular morphologic traits in the American Cocker Spaniel may confer primary angle closure glaucoma susceptibility
  Scientific Reports
  (November 2022)
  Park S, Casanova MI, Bannasch DL, Daley NL, Kim S, Kuchtey J, Gomes FE, Leonard BC, Good KL, Da Costa Martins B, Murphy CJ, Thomasy SM

  Topical Ripasudil for the treatment of primary corneal endothelial degeneration in dogs
  Translational Vision Science and Technology
  (September 2022)
  Michalak SR, Kim S, Park S, Casanova MI, Bowman MAW, Ferneding M, Leonard BC, Good KL, Li JY, Thomasy SM
   

  Pain Management

  Twice-daily oral administration of a cannabidiol and cannabidiolic acid-rich hemp extract was well tolerated in orange-winged Amazon parrots (Amazona amazonica) and has a favorable pharmacokinetics profile
  American Journal of Veterinary Research
  (February 2023)
  Sosa-Higareda M, Sanchez-Migallon Guzman D, Knych H, Lyubimov A, Zakharov A, Gomez B, Beaufrere H

  Respiratory

  Prospective evaluation of the efficacy of inhaled steroids administered via the AeroDawg spacing chamber in management of dogs with chronic cough
  Journal of Veterinary Internal Medicine
  (March 2023)
  Chan JC, Johnson LR

  Surgery/Orthopedics

  Metal reactivity is present in dogs with tibial plateau leveling osteotomy and total hip replacement implants
  American Journal of Veterinary Research
  (January 2023)
  Filliquist B, McKay R, Marcellin-Little DJ, Irvin JJ, Garcia TC, Vernau W, Chou PY, Kapatkin AS, Vapniarsky N

   

   

• 2021-2022 CCAH published donor funded studies:

• Anesthesia

  Cardiovascular and gas exchange effects of individualized positive end-expiratory pressures in cats anesthetized with isoflurane
  Frontiers in Veterinary Science
  (May 2022)
  Machado ML, Soares JHN, Pypendop BH, Aguiar AJA, Braun C, Motta-Ribeiro GC, Jandre FC
  
  Pharmacokinetics of butorphanol in male neutered cats anesthetized with isoflurane
  Journal of Veterinary Pharmacology and Therapeutics
  (September 2021)
  Pypendop BH, Shilo-Benjamin Y
  
  Pharmacokinetics of grapiprant administered to red-tailed hawks (Buteo jamaicensis) after food was withheld for 24 hours
  ­American Journal of Veterinary Research
  (November 2021)
  Rodriguez P, Paul-Murphy JR, Knych HK, Drazenovich TL, Hawkins MG

  Behavior

  How does the social grouping of animals in nature protect against sickness? A perspective
  Frontiers in Behavioral Neuroscience
  (July 2021)
  Hart LA, Hart BL
  
  Stress-related behaviors in companion dogs exposed to common household noises, and owners' interpretations of their dogs' behavior
  Frontiers in Behavioral Neuroscience
  (November 2021)
  Grigg EK, Chou J, Parker E, Gatesy-Davis A, Clarkson ST, Hart LA

  Assessing the relationship between the emotional states of dogs and their human handlers, using simultaneous behavioral and cardiac measures
  Frontiers in Veterinary Science
  (July 2022)
  Grigg EK, Liu S, Dempsey DG, Wong K, Bain M, Sollers JJ, Haddock R, Kogan LR, Barnhard JA, Tringali AA, Thigpen AP, Hart, LA

  Companion animals’ roles for AIDS survivors, mostly aging males, during HIV/AIDS and COVID-19 pandemics
  Animals
  (June 2022)
  Hart, LA , Thigpen AP, Fine AH, Gorczyca K, Willits N, Bernaldo R, Malzyner S, Guillén, D’Amato K

  Cancer 

  Novel clonality assays for T cell lymphoma in cats targeting the T cell receptor beta, T cell receptor delta, and T cell receptor gamma loci
  Journal of Veterinary Internal Medicine
  (November 2021)
  Radtanakatikanon A, Moore PF, Keller SM, Vernau W

  T Cell immune profiles of blood and tumor in dogs diagnosed with malignant melanoma
  Frontiers in Veterinary Science
  (December 2021)
  Sparger EE, Hong C, Ning C, Rebhun RB, Withers SS, Kieu H, Canter RJ, Monjazeb AM, Kent MS

  Pre-clinical and clinical evaluation of the HYPERSCINT plastic scintillation dosimetry research platform for in vivo dosimetry during radiotherapy
  Journal of Applied Clinical Medical Physics
  (February 2022)
  Schoepper I, Dieterich S, Trestrail EA, Kent MS

  Retrospective immunohistochemical investigation of suspected non-visceral leiomyosarcoma in dogs
  Journal of Veterinary Diagnostic Investigation
  (March 2022)
  Brady RV, Rebhun RB, Skorupski KA, Burton JH, Al-Nadaf S, Choi E, Willcox JL
  
  Application of Bayesian regression for the identification of a catchment area for cancer cases in dogs and cats
  Frontiers in Veterinary Science
  (July 2022)
  Díaz Cao JM, Kent MS, Rupasinghe R, Martínez-López B

  Cardiology 

  Comparative assessment of heart rate variability obtained via ambulatory ECG and polar heart rate monitors in healthy cats: A pilot study
  Frontiers in Veterinary Science
  (November 2021)
  Grigg EK, Ueda Y, Walker AL, Hart LA, Simas S, Stern JA

  Platelet priming and activation in naturally occurring thermal burn injuries and wildfire smoke exposure is associated with intracardiac thrombosis and spontaneous echocardiographic contrast in feline survivors
  Frontiers in Veterinary Science
  (July 2022)
  Tan AWK, Li RHL, Ueda Y, Stern JA, Hussain M, Haginoya S, Sharpe AN, Gunther-Harrington CT, Epstein SE, Nguyen N

  Dentistry 

  Biomechanical evaluation of locking vs. non-locking 2.0-mm malleable L-miniplate fixation of simulated caudal mandibular fractures in cat
  American Journal of Veterinary Research
  (June 2022)
  Kot CCS, Verstraete FJM, Garcia TC, Stover SM, Arzi B

  The diagnostic yield of cone-beam computed tomography for degenerative changes of the temporomandibular joint in dogs
  Frontiers in Veterinary Science
  (August 2021)
  McKay RM, Vapniarsky N, Hatcher D, Carr N, Chen S, Verstraete FJM, Cissell DD, Arzi B

  Genetics 

  Fine-tuning p53 activity by modulating the interaction between eukaryotic translation initiation factor eIF4E and RNA-binding protein RBM38
  Genes & Development
  (February 2021)
  Sun W, Laubach K, Lucchessi CL, Zhang Y, Chen M, Zhang J, Chen X

  The effects of FGF4 retrogenes on canine morphology
  Genes
  (February 2022)
  Bannasch D, Batcher K, Leuthard F, Bannasch M, Hug P, Marcellin-Little DJ, Dickinson PJ, Drögemüller M, Drögemüller C, Leeb T

  Recent, full-length gene retrocopies are common in canids
  Genome
  (August 2022)
  Batcher K, Varney S, York D, Blacksmith M, Kidd JM, Rebhun R, Dickinson P, Bannasch D

  Infectious Disease 

  Serotype I and II feline coronavirus replication and gene expression patterns of feline cells—building a better understanding of serotype I FIPV biology
  Viruses
  (June 2022)
  Cook S, Castillo D, Williams S, Haake C, Murphy B
  
  Pharmacokinetics of isavuconazole in healthy cats after oral and intravenous administration
  Journal of Veterinary Internal Medicine 
  (May 2022)
  Woerde DJ, Wittenburg LA, Dear JD

  Nutrition 

  Determination of mammalian deoxyribonucleic acid in commercial canine treats and supplements
  Journal of American Animal Hospital Association
  (April 2021)
  Perez Marquez B, Larsen JA, Fascetti AJ

  Spay / Neuter

  An ancient practice but a new paradigm: Personal choice for the age to spay or neuter a dog
  Frontiers in Veterinary Science
  (March 2021)
  Hart, LA, Hart BL

  Stem Cell 

  Panobinostat effectively increases histone acetylation and alters chromatin accessibility landscape in canine embryonic fibroblasts but does not enhance cellular reprogramming
  Frontiers in Veterinary Science
  (September 2021)
  Moshref M, Questa M, Lopez-Cervantes V, Sears TK, Greathouse RL, Crawford CK, Kol A

  Surgery / Orthopedics 

  Comparison of 18F-sodium fluoride positron emission tomography and CT: An exploratory study in 12 dogs with elbow pain
  American College of Veterinary Radiology
  (January 2021)
  McLarty E, Spriet M, Beylin D, Chou P, Filliquist B, Marcellin-Little DJ, Kapatkin AS

  Tissue engineering of canine cartilage from surgically debrided osteochondritis dissecans fragments
  Annals of Biomedical Engineering
  (December 2021)
  Vapniarsky N, Moncada L, Garrity C, Wong A, Filliquist B, Chou P, Kapatkin A, Marcelin-Little DJ

  Long-term assessment of bone regeneration in nonunion fractures treated with compression-resistant matrix and recombinant human bone morphogenetic protein-2 in dogs
  Veterinary and Comparative Orthopaedics and Traumatology
  (April 2022)
  Castilla A, Filliquist B, Spriet M, Garcia TC, Arzi B, Chou P, Kapatkin AS
  
  Evaluation of transanal minimally invasive surgery for submucosal rectal resection in cadaveric canine specimens
  The American College of Veterinary Surgeons
  (August 2020)
  Mayhew PD, Balsa IM, Guerzon CN, Gibson EA, Keel MK, Brun MV, Araya FJL

  Urology  

  Presentation variables associated with the development of severe post-obstructive diuresis in male cats following relief of urethral obstruction
  Frontiers in Veterinary Science
  (April 2022)
  Muller KM, Burkitt-Creedon JM, Epstein SE

• 2020-2021 CCAH published donor funded studies:

• Canine

  Cancer
  Glioma-associated microglia/macrophages augment tumorigenicity in canine astrocytoma, a naturally occurring model of human glioma
  Neuro-Oncology Advances (May 2021)
  Toedebusch R, Grodzki AC, Dickinson PJ, Woolard K, Vinson N, Sturges B, Snyder J, Li CF, Nagasaka O, Consales B, Vernau K, Knipe M, Murthy V, Lein PJ, Toedebusch CM

  Development of canine PD-1/PD-L1 specific monoclonal antibodies and amplification of canine T cell function 
  PLOS ONE (July 2020)
  Choi JW, Withers SS, Chang H, Spanier JA, De La Trinidad VL, Panesar H, Fife BT, Sciammas R, Sparger EE, Moore PF, Kent MS, Rebhun RB, McSorley SJ

  Evaluation of accuracy for 18F-FDG positron emission tomography and computed tomography for detection of lymph node metastasis in canine oral malignant melanoma
  Veterinary and Comparative Oncology (August 2020)
  Willcox JL, Spriet M, Zwingenberger AL, Phillips KL, Burton JH, Skorupski KA, Hansen KS, Affolter VK, Woolard KD, Beylin D, Giuffrida MA

  Cardiology
  Reproducibility of echocardiographic indices of left atrial size in dogs with subclinical myxomatous mitral valve disease
  Journal of Veterinary Internal Medicine (June 2020)
  Hsue W, Visser LC

  Diabetes
  Loss of sympathetic innervation to islets of Langerhans in canine diabetes and pancreatitis is not associated with insulitis
  Nature Research (November 2020)
  Gilor C, Pires J, Greathouse R, Horn R, Huising MO, Marks SL, Murphy B, Kol A

  Nutrition
  Impact of storage temperature, storage duration, and deproteinization on plasma amino acid concentrations in dogs
  Research in Veterinary Science (March 2021)
  Chiang C, Larsen JA, Sahtout M, Horoschak RE, Yu Z, Fascetti AJ

  Surgery
  A randomized controlled trial of three-dimensional versus two-dimensional imaging system on duration of surgery and mental workload for laparoscopic gastropexies in dogs
  Veterinary Surgery (July 2021)
  Balsa IM, Giuffrida MA, Mayhew PD

  Assisting Decision-Making on Age of Neutering for Mixed Breed Dogs of Five Weight Categories: Associated Joint Disorders and Cancers
  Frontiers in Veterinary Science (July 2020)
  Hart BL, Hart LA, Thigpen AP, Willits NH.

  Assisting Decision-Making on Age of Neutering for 35 Breeds of Dogs: Associated Joint Disorders, Cancers, and Urinary Incontinence
  Frontiers in Veterinary Science (July 2020)
  Hart BL, Hart LA, Thigpen AP, Willits NH

  Influence of interlocking thread screws to repair simulated adult canine humeral condylar fractures
  Veterinary Surgery (August 2021)
  Raleigh JS, Filliquist B, Kapatkin AS, Chou PY, Marcellin-Little DJ, Garcia TC, Jacques KL, Stover SM

  Percutaneous radiologically guided gastrostomy tubes: Procedural description and biomechanical comparison in a canine model
  Veterinary Surgery (October 2020)
  Griffin MA, Culp WTN, Garcia TC, Glaiberman CB, Giuffrida MA, Balsa IM, Mayhew PD, Johnson EG, Marks SL

  Genetics
  Chromatin accessibility in canine stromal cells and its implications for canine somatic cell reprogramming
  Stem Cells Translational Medicine (November 2020)
  Questa M, Moshref M, Jimenez RJ, Lopez-Cervantes V, Crawford CK, Settles ML, Ross PJ, Kol A

  Multiple FGF4 Retrocopies Recently Derived within Canids
  Genes 2020 (July 2020)
  Batcher K, Dickinson P, Maciejczyk K, Brzeski K, Rasouliha SH, Letko A, Drögemüller C, Leeb T, Bannasch D

  A Missense Variant in ALDH5A1 Associated with Canine Succinic Semialdehyde Dehydrogenase Deficiency (SSADHD) in the Saluki Dog
  Genes 2020 (September 2020)
  Vernau KM, Struys E, Letko A, Woolard KD, Aguilar M, Brown EA, Cissell DD, Dickinson PJ, Shelton GD, Broome MR, Gibson KM, Pearl PL, König F, Van Winkle TJ, O’Brien D, Roos B, Matiasek K, Jagannathan V, Drögemüller C, Mansour TA, Brown CT, Bannasch DL

  Quality of DNA extracted from formalinfixed, paraffin-embedded canine tissues
  Journal of Veterinary Diagnostic Investigation (July 2020)
  Dear JD, Sykes JE, Bannasch DL

  Liver Disease
  Ferumoxytol-enhanced magnetic resonance angiography provides comparable vascular conspicuity to CT angiography in dogs with intrahepatic portosystemic shunts
  Veterinary Radiology and Ultrasound  (July 2021)  
  Wilson S, Culp WTN, Wisner ER, Cissell DD, Finn JP, Zwingenberger AL

  Surgery - Orthopedics
  Comparison of needle arthroscopy, traditional arthroscopy, and computed tomography for the evaluation of medial coronoid disease in the canine elbow
  Veterinary Surgery (July 2021) 
  Hersh-Boyle RA, Chou PY, Kapatkin AS, Spriet M, Filliquist B, Garcia TC, Marcellin-Little DJ

  Blood Clotting
  Lipopolysaccharide-Activated Canine Platelets Upregulate High Mobility Group Box-1 via Toll-Like Receptor 4
  Frontiers in Veterinary Science (June 2021)
  Li RHL, Hommel C, Nguyen N.

  Analgesia/Pain Control
  Pharmacokinetics of a high-concentration formulation of buprenorphine (Simbadol) in male dogs
  Veterinary Anaesthesia and Analgesia (July 2021)
  Hansford J, Henao-Guerrero N, Machado ML, Pypendop BH

  Comparison of the efficacy and duration of desensitization of oral structures following injection of a lidocaine-bupivacaine mixture via lateral percutaneous and modified infraorbital approaches in dogs
  American Journal of Veterinary Research (January 2021)
  Chohan AS, Pascoe PJ

  Internal Medicine
  Efficacy of a micronized, nanocrystal fenofibrate formulation in treatment of hyperlipidemia in dogs
  Journal of Veterinary Internal Medicine (July 2021)
  Munro MJL, Hulsebosch SE, Marks SL, Gilor C

  Feline

  Phenylpiperidine opioid effects on isoflurane minimum alveolar concentration in cats
  Journal of Veterinary Pharmacology and Therapeutics (November 2020) 
  Brosnan RJ, Pypendop BH, Stanley SD

  Reference intervals for radiographic, echocardiographic and N-terminal pro B-type natriuretic peptide values in healthy kittens
  Journal of Feline Medicine and Surgery (April 2021) 
  Gunther-Harrington CT, Sharpe AN, Vernau KM, Ueda Y, Montgomery EA, Surmick JD, Fernandez N, Ontiveros E, Walker AL, Stern JA

  Stem cell therapy prior to full-mouth tooth extraction lacks substantial clinical efficacy in cats affected by chronic gingivostomatitis
  Journal of Feline Medicine and Surgery (September 2020)
  Arzi B, Taechangam N, Lommer MJ, Walker NJ, Loscar MR, Borjesson DL

  Stem cell therapy prior to full-mouth tooth extraction lacks substantial clinical efficacy in cats affected by chronic gingivostomatitis
  Journal of Feline Medicine and Surgery (September 2020)
  Arzi B, Taechangam N, Lommer MJ, Walker NJ, Loscar MR, Borjesson DL

  Rabbit Carcasses for Use in Feline Diets: Amino Acid Concentrations in Fresh and Frozen Carcasses With and Without Gastrointestinal Tracts
  Frontiers in Veterinary Science (January 2021)
  Owens TJ, Fascetti AJ, Calvert CC, Larsen JA

  Avian & Exotic Animals

  Varying Expression of Mu and Kappa Opioid Receptors in Cockatiels (Nymphicus hollandicus) and Domestic Pigeons (Columba livia domestica)
  Frontiers in Genetics (October 2020)
  Fousse SL, Golsen BM, Sanchez-Migallon Guzman D, Paul-Murphy JR, Stern JA

  Pharmacokinetics of hydromorphone hydrochloride after intramuscular and intravenous administration of a single dose to orange-winged Amazon parrots (Amazona amazonica)
  American Journal of Veterinary Medicine (November 2020)
  Sanchez-Migallon Guzman D, Knych, H, Douglas, J, Paul-Murphy, JR

  Pharmacokinetics of amantadine after oral administration of single and multiple doses to orange-winged Amazon parrots ( Amazona amazonica)
  American Journal of Veterinary Medicine (August 2020)
  Berg KJ, Sanchez-Migallon Guzman D, Knych HK, Drazenovich TL, Paul-Murphy JR

  Pharmacokinetic and Efficacy Study of Acyclovir Against Cyprinid Herpesvirus 3 in Cyprinus carpio
  Frontiers in Veterinary Science (October 2020)
  Quijano Cardé EM, Yazdi Z, Yun S, Hu R, Knych H, Imai DM, Soto E

  Evaluation of the thermal antinociceptive effects of hydromorphone hydrochloride after intramuscular administration to orange-winged Amazon parrots (Amazona amazonica)
  American Journal of Veterinary Medicine (October 2020)
  Sanchez-Migallon Guzman D, Douglas JM, Beaufrère H, Paul-Murphy JR

• 2019-2020 CCAH published donor-funded studies:

• Canine

  Cancer
  Use of transrectal ultrasonography for assessment of the size and location of prostatic carcinoma in dogs
  American Journal of Veterinary Research (November 2019)
  Culp, WTN, Johnson, E, Giufridda, MA, Palm, CA, Mayhew, P, Kent, MS, Rebhun, RB, Burton, JH
  
  The interaction between RUNX2 and core binding factor beta as a potential therapeutic target in canine osteosarcoma
  Veterinary and Comparative Oncology (March 2020)
  Alegre, F, Ormonde, AR, Godinez, DR, Illendula, A, Bushweller, JH, Wittenburg, LA
  
  Intramuscular diphenhydramine does not affect acute doxorubicin infusion-related arrhythmia number or severity in a prospective crossover study in canine lymphoma: A Pilot Study 
  Frontiers in Veterinary Science (July 2020)
  Willcox, JL, Belanger, C, Burton, JH, Yu, L, Yu, U, Visser, LC, Skorupski, K, Stern, JA
  
  Clinicopathological characteristics of histiocytic sarcoma affecting the central nervous system in dogs
  Journal of Veterinary Internal Medicine (March 2020)
  Toyoda, I, Vernau, W, Sturges, BK, Vermau, KM, Rossmeisl, J, Zimmerman, K, Crose, CM, Woolard, K, Gufridda, M, Higgins, RJ, Dickenson, PJ
  
  Hematology
  Canine platelets express functional Toll-like receptor-4: lipopolysaccharide-triggered platelet activation is dependent on adenosine diphosphate and thromboxane A2 in dogs
  BMC Veterinary Research (July 2019)
  Li, RHL, Nguyen, N, Tablin, F
  
  Genetics
  Pigment Intensity in Dogs is Associated with a Copy Number Variant Upstream of KITLG
  Genes (Basel) (January 2020)
  Weich, K, Affolter, V, York, D, Rebhun, R, Kallenberg, A, Bannasch, D
  
  Surgery
  Comparison of the efficacy and duration of desensitization of oral structures following injection of various volumes of a lidocaine-bupivacaine mixture via an infraorbital approach in dogs
  American Journal of Veterinary Research (July 2020)
  Pascoe PJ, Chohan AS.
  
  Utility of bronchoscopy combined with surgery in the treatment and outcomes of dogs with intrathoracic disease secondary to plant awn migration
  Veterinary Surgery (July 2019)
  Gibson EA, Balsa IM, Mayhew PD, Phillips, K, Giuffrida, MA, Culp, WTN, Steffey, MA, Johnson, LR

  Feline

  Dentistry
  A multicenter experience using adipose-derived mesenchymal stem cell therapy for cats with chronic, non-responsive gingivostomatitis
  Stem Cell Research & Therapy (March 2020)
  Arzi, B, Peralta, S, Fiani, N, Vapniarsky, N, Taechangam, N, Delatorre, U, Clark, KC, Walker, N, Loscar, M, Lommer, MJ, Fulton, M, Battig, J, Borjesson, D
  
  Assessment of P2Y12 Inhibition by Clopidogrel in Feline Platelets Using Flow Cytometry Quantification of Vasodilator-Stimulated Phosphoprotein Phosphorylation
  Frontiers in Veterinary Science (April 2020)
  Li RHL, Nguyen N, Rosati T, Jandrey K
  
  Immunology
  Topology and expressed repertoire of the Felis catus T cell receptor loci
  BMC Genomics (January 2020)
  Radtanakatikanon A, Keller SM, Darzentas N, Moore, PF, Folch, G, Ngoune VN, Lefranc, MP, Vernau, W
  
  Infectious Disease 
  Perspectives: potential therapeutic options for SARS-CoV-2 patients based on feline infectious peritonitis strategies: central nervous system invasion and drug coverage
  International Journal of Antimicrobial Agents (June 2020)
  Olsen, M, Cook, SE, Huang, V, Perdersen, N, Murphy, BG
  
  Surgery
  Cardiopulmonary effects of dexmedetomidine, with and without vatinoxan, in isoflurane-anesthetized cats 
  Veterinary Anaesthesia and Analgesia (November 2019)
  Jaeger AT, Pypendop BH, Ahokoivu H, Honkavaara J
  
  Hematology
  Effects of famciclovir in cats with spontaneous acute upper respiratory tract disease
  Journal of Feline Medicine and Surgery (June 2020)
  Kopecny L, Maggs DJ, Leutenegger CM, Johnson LR
  An RNA-directed gene editing strategy for Attenuating the infectious potential of feline immunodeficiency virus-infected cells: a proof of concept
  Viruses (May 2020)
  Murphy, BG, Wolf, T, Vogel, H, Castillo, D, Woolard, K

  Avian, Reptile & Other Companion Animals

  Gastrointestinal
  Pharmacokinetics of maropitant citrate in New Zealand White rabbits ( Oryctolagus cuniculus) 
  American Journal of Veterinary Research, (October 2019)
  Ozawa, SM, Hawkins, MG, Drazenovich, TL, Kass, PH, Knych, K
  
  Cancer
  Evaluation of deslorelin implant on subsequent mammary tumors of rats (Rattus norvegicus)
  Journal of Exotic Pet Medicine (October 2019)
  Vergneau-Grosset, C, Peña, L, Cluzel, C, Hawkins, MG, Maccolini, E, Sinclair, K, Graham, J, Sadar, MJ, Guzman, DS-M, Lair, S, Langlois, I, Paul-Murphy, J
  
  Infectious Disease 
  The formation, persistence, and resistance to disinfectant of the Erysipelothrix piscisicarius biofilm
  Journal of Aquatic Animal Health (January 2020)
  Pomaranski, E, Soto, E
  
  Non-lethal diagnostic methods for koi herpesvirus in koi Cyprinus carpio
  Diseases of Aquatic Organisms (March 2020)
  Soto, E, Tamez-Trevino, E, Yarzdi, Z, Stevens, BN, Yun, S, Martinez-Lopez, B, Burges, J 
  
  Surgery
  Evaluation of a ventral and a left lateral approach to coelioscopy in bearded dragons ( Pogona vitticeps) 
  American Journal of Veterinary Research, (March 2020)
  Frei, S, Guzman, DS-M, Kass, PH, Giuffrida, MA, Mayhew, PD

• 2018-2019 CCAH published donor-funded studies
• Cancer
  Investigation of immune cell markers in feline oral squamous cell carcinoma
  Veterinary Immunology and Immunopathology (Feb. 2019)
  Sparger EE, Murphy BG, Kamal FM, Arzi B, Naydan D, Skouritakis K, Cox DP, Skorupski K.
  
  Association of macrophage and lymphocyte infiltration with outcome in canine osteosarcoma
  Veterinary and Comparative Oncology (Mar. 2019)
  Withers SS, Skorupski KA, York D, Choi JW, Woolard KD, Laufer-Amorim R, Sparger EE, Rodriguez CO, McSorley SJ, Monjazeb AM, Murphy WJ, Canter
  RJ, Rebhun RB
  
  Cardiology
  Cardiac effects of a single dose of pimobendan in cats with hypertrophic cardiomyopathy; a randomized, placebo-controlled, crossover study
  Frontiers in Veterinary Science (Feb. 2019)
  Oldach MS, Ueda Y, Ontiveros ES, Fousse SL, Harris SP, Stern JA
  
  Echocardiographic evaluation of velocity ratio, velocity time integral ratio, and pulmonary valve area in dogs with pulmonary valve stenosis
  Journal of Veterinary Internal Medicine (Sep. 2018)
  Nishimura S, Visser LC, Bélanger C, Oldach MS, Gunther-Harrington CT, Stern JA
  
  Emergency Medicine
  Efficacy of manual ventilation techniques during cardiopulmonary resuscitation in dogs
  Frontiers in Veterinary Science (Oct. 2018)
  Hopper K, Rezende ML, Borchers A, Epstein SE
  
  Genetics
  Genetic heterogeneity and diversity of North American golden retrievers using a low density STR marker pane
  PLOS One (Feb.2019)
  Ontiveros ES, Hughes S, Penedo MCT, Grahn RA, Stern JA
  
  Genetics-Ophthalmology
  Evaluation of the major histocompatibility complex (MHC) class II as a candidate for sudden acquired retinal degeneration syndrome (SARDS) in dachshunds
  Veterinary Ophthalmology (Feb. 2019)
  Stromberg SJ, Thomasy SM, Marangakis AD, Kim S, Cooper AE, Brown EA, Maggs DJ, Bannasch DL
  
  Hematology
  Influence of needle gauge used for venipuncture on measures of hemostasis in cats
  Journal of Feline Medicine Surgery (Feb. 2019)
  Solbak S, Epstein SE, Hopper K
  
  Immunology
  Multi-color flow cytometry for evaluating age-related changes in memory lymphocyte subsets in dogs
  Development & Comparative Immunology (Oct. 2018)
  Withers SS, Moore PF, Chang H, Choi JW, McSorley SJ, Kent MS, Monjazeb AM, Canter RJ, Murphy WJ, Sparger EE, Rebhun RB
  
  Infectious Disease
  Pilot study of the safety and solerability of asubconjunctival penciclovir implant in cats experimentally infected with herpesvirus
  Journal of Ocular Pharmacology and Therapeutics (Jan/Feb 2019)
  Covert JC, Thomasy SM, Kado-Fong H, Kon LN, Kass PH, Reilly CM, Lappin MR, Margulies BJ, Maggs DJ
  
  Babesia conradae infection in coyote hunting dogs infected with multiple blood-borne pathogens
  Journal of Veterinary Internal Medicine (Sep. 2018)
  Dear JD, Owens SD, Lindsay LL, Biondo AW, Chomel BB, Marcondes M, Sykes JE
  
  Neurology
  Intracranial pressure monitoring in normal dogs usingsubdural and intraparenchymal miniature strain-gauge transducers
  Journal of Veterinary Internal Medicine (Mar 2019)
  Sturges BK, Dickinson PJ, Tripp LD, Udaltsova I, LeCouteur RA
  
  Pharmacokinetics and safety of zonisamide after oral administration of single and multiple doses to Hispaniolan Amazon parrots
  American Journal of Veterinary Research (Feb. 2019)
  Keller KA, Guzman DS, Boothe DM, Visser M, de Matos RE, Petritz OA, Kass PH, Paul-Murphy JR
  
  Nutrition
  Determination of total mercury and methylmercury concentrations in commercial canine diets
  Topics in Companion Animal Medicine (June 2019)
  Sires RA, Fascetti AJ, Puschner B, Larsen JA
  
  Pain Management
  Evaluation of the thermal antinociceptive effects and pharmacokinetics after intramuscular administration of buprenorphine hydrochloride to cockatiels (Nymphicus hollandicus)
  American Journal of Veterinary Research (Dec. 2018)
  Guzman DS, Houck EL, Knych HKD, Beaufrère H, Paul-Murphy JR
  
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